CD46

CD46

Protein CD46 PDB 1ckl.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3O8E, 1CKL, 2O39, 3INB, 3L89, 5FO8

Identifiers

CD46, AHUS2, MCP, MIC10, TLX, TRA2.10, CD46 molecule

External IDs

OMIM: 120920 MGI: 1203290 HomoloGene: 7832 GeneCards: CD46

Genetically Related Diseases

Gene ontology
Molecular function	• virus receptor activity • cadherin binding • protein binding • receptor activity • complement binding • endopeptidase activity • enzyme inhibitor activity
Cellular component	• integral component of membrane • inner acrosomal membrane • membrane • focal adhesion • plasma membrane • integral component of plasma membrane • cell surface • extracellular exosome • cytoplasmic vesicle • acrosomal vesicle • cytoplasm • Golgi apparatus • basolateral plasma membrane
Biological process	• T cell mediated immunity • adaptive immune response • positive regulation of interleukin-10 production • immune system process • sequestering of extracellular ligand from receptor • positive regulation of regulatory T cell differentiation • negative regulation of gene expression • single fertilization • positive regulation of gene expression • positive regulation of T cell proliferation • positive regulation of memory T cell differentiation • complement activation, classical pathway • positive regulation of transforming growth factor beta production • viral entry into host cell • viral process • regulation of Notch signaling pathway • regulation of complement activation • interleukin-10 production • innate immune response • proteolysis • negative regulation of catalytic activity • negative regulation of complement activation
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE CD46 208783 s at fs.png

PBB GE CD46 211574 s at fs.png

PBB GE CD46 207549 x at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


4179


17221


ENSG00000117335


ENSMUSG00000016493


P15529


O88174

RefSeq (mRNA)

NM_002389 NM_153826 NM_172350 NM_172351 NM_172352
NM_172353 NM_172354 NM_172355 NM_172356 NM_172357 NM_172358 NM_172359 NM_172360 NM_172361


NM_010778

RefSeq (protein)

NP_002380 NP_722548 NP_758860 NP_758861 NP_758862
NP_758863 NP_758869 NP_758871


NP_034908.1 NP_034908

Location (UCSC)

Chr 1: 207.75 – 207.8 Mb

Chr 1: 195.04 – 195.09 Mb

PubMed search

3O8E, 1CKL, 2O39, 3INB, 3L89, 5FO8

ENSG00000117335

ENSMUSG00000016493

NM_172353
NM_172354
NM_172355
NM_172356
NM_172357
NM_172358
NM_172359
NM_172360
NM_172361

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Wikipedia

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