CD45

PTPRC

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1YGU, 1YGR, 5FMV, 5FN6, 5FN7

Identifiers

Aliases

PTPRC, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C

External IDs

MGI: 97810 HomoloGene: 2126 GeneCards: PTPRC

Genetically Related Diseases

ulcerative colitis

Gene ontology
Molecular function	• phosphoprotein phosphatase activity • phosphatase activity • protein binding • transmembrane receptor protein tyrosine phosphatase activity • protein kinase binding • hydrolase activity • protein tyrosine phosphatase activity
Cellular component	• integral component of membrane • membrane • focal adhesion • plasma membrane • integral component of plasma membrane • cell surface • membrane raft • extracellular exosome • external side of plasma membrane
Biological process	• B cell receptor signaling pathway • cell cycle phase transition • release of sequestered calcium ion into cytosol • negative regulation of protein kinase activity • bone marrow development • stem cell development • protein dephosphorylation • negative regulation of cytokine-mediated signaling pathway • positive regulation of hematopoietic stem cell migration • regulation of cell cycle • negative regulation of cell adhesion involved in substrate-bound cell migration • negative regulation of T cell mediated cytotoxicity • cell surface receptor signaling pathway • B cell proliferation • T cell differentiation • positive regulation of B cell proliferation • defense response to virus • positive regulation of T cell proliferation • hematopoietic progenitor cell differentiation • positive regulation of antigen receptor-mediated signaling pathway • immunoglobulin biosynthetic process • T cell receptor signaling pathway • positive regulation of stem cell proliferation • dephosphorylation • positive regulation of protein kinase activity • peptidyl-tyrosine dephosphorylation • response to gamma radiation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5788


19264

Ensembl


ENSG00000081237


ENSMUSG00000026395

UniProt


P08575


P06800

RefSeq (mRNA)


NM_001267798 NM_002838 NM_080921 NM_080922


NM_001111316 NM_001268286 NM_011210

RefSeq (protein)


NP_001254727 NP_002829 NP_563578 NP_563578.2 NP_002829.3


n/a

Location (UCSC)

Chr 1: 198.64 – 198.76 Mb

Chr 1: 138.06 – 138.18 Mb

PubMed search

1YGU, 1YGR, 5FMV, 5FN6, 5FN7

NM_001267798
NM_002838
NM_080921
NM_080922

NM_001111316
NM_001268286
NM_011210

NP_001254727
NP_002829
NP_563578
NP_563578.2
NP_002829.3

...
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