CD4+

CD4

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1CDH, 1CDI, 1CDJ, 1CDU, 1CDY, 1G9M, 1G9N, 1GC1, 1JL4, 1Q68, 1RZJ, 1RZK, 1WIO, 1WIP, 1WIQ, 2B4C, 2JKR, 2JKT, 2KLU, 2NXY, 2NXZ, 2NY0, 2NY1, 2NY2, 2NY3, 2NY4, 2NY5, 2NY6, 2QAD, 3B71, 3CD4, 3JWD, 3JWO, 3LQA, 3O2D, 3S5L, 3T0E, 4JM2, 1WBR, 3S4S, 4H8W, 4P9H, 4Q6I, 4R2G, 4R4H, 4RQS, 3J70, 5A7X, 5A8H, 5CAY

Identifiers

Aliases

CD4, CD4mut, CD4 molecule

External IDs

MGI: 88335 HomoloGene: 513 GeneCards: CD4

Gene ontology
Molecular function	• transmembrane signaling receptor activity • virus receptor activity • receptor activity • glycoprotein binding • MHC class II protein binding • protein homodimerization activity • zinc ion binding • protein tyrosine kinase binding • extracellular matrix structural constituent • enzyme binding • immunoglobulin binding • protein binding • coreceptor activity • protein kinase binding
Cellular component	• endoplasmic reticulum lumen • integral component of membrane • early endosome • membrane • cell surface • endoplasmic reticulum membrane • membrane raft • T cell receptor complex • external side of plasma membrane • plasma membrane • clathrin-coated vesicle membrane
Biological process	• transmembrane receptor protein tyrosine kinase signaling pathway • T cell costimulation • positive regulation of interleukin-2 biosynthetic process • defense response to Gram-negative bacterium • positive regulation of protein kinase activity • regulation of defense response to virus by virus • positive regulation of calcium-mediated signaling • signal transduction • helper T cell enhancement of adaptive immune response • T cell selection • response to estradiol • induction by virus of host cell-cell fusion • adaptive immune response • response to vitamin D • T cell differentiation • cell surface receptor signaling pathway • positive regulation of T cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • enzyme linked receptor protein signaling pathway • entry into host cell • T cell activation • positive regulation of T cell activation • maintenance of protein location in cell • cytokine production • T cell receptor signaling pathway • immune system process • positive regulation of calcium ion transport into cytosol • regulation of T cell activation • immune response • cell adhesion • viral process • fusion of virus membrane with host plasma membrane • membrane organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


920


12504

Ensembl


ENSG00000010610


ENSMUSG00000023274

UniProt


P01730


P06332

RefSeq (mRNA)


NM_000616 NM_001195014 NM_001195015 NM_001195016 NM_001195017


NM_013488

RefSeq (protein)


NP_000607 NP_001181943 NP_001181944 NP_001181945 NP_001181946


NP_038516.1 NP_038516

Location (UCSC)

Chr 12: 6.79 – 6.82 Mb

Chr 6: 124.86 – 124.89 Mb

PubMed search

CD4, Cluster of differentiation 4, extracellular

structure of t-cell surface glycoprotein cd4, monoclinic crystal form

Identifiers

Symbol

CD4-extrcel

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

1CDH, 1CDI, 1CDJ, 1CDU, 1CDY, 1G9M, 1G9N, 1GC1, 1JL4, 1Q68, 1RZJ, 1RZK, 1WIO, 1WIP, 1WIQ, 2B4C, 2JKR, 2JKT, 2KLU, 2NXY, 2NXZ, 2NY0, 2NY1, 2NY2, 2NY3, 2NY4, 2NY5, 2NY6, 2QAD, 3B71, 3CD4, 3JWD, 3JWO, 3LQA, 3O2D, 3S5L, 3T0E, 4JM2, 1WBR, 3S4S, 4H8W, 4P9H, 4Q6I, 4R2G, 4R4H, 4RQS, 3J70, 5A7X, 5A8H, 5CAY

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