CD34

CD34
Identifiers
Aliases	CD34, entrez:947
External IDs	OMIM: 142230 MGI: 88329 HomoloGene: 1343 GeneCards: CD34
Gene ontology Molecular function • transcription factor binding • sulfate binding • carbohydrate binding Cellular component • cytoplasm • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • extracellular region • cell surface • basal plasma membrane • glomerular endothelium fenestra • apical plasma membrane • intercellular bridge • perinuclear region of cytoplasm • lysosome • external side of plasma membrane • cell periphery Biological process • single organismal cell-cell adhesion • hemopoiesis • extracellular exosome assembly • stem cell proliferation • positive regulation of interleukin-10 production • negative regulation of interleukin-2 secretion • cell motility • negative regulation of blood coagulation • positive regulation of glial cell-derived neurotrophic factor secretion • metanephric glomerular mesangial cell differentiation • paracrine signaling • hematopoietic stem cell proliferation • positive regulation of granulocyte colony-stimulating factor production • negative regulation of gene expression • positive regulation of angiogenesis • regulation of blood pressure • vascular wound healing • positive regulation of gene expression • glomerular filtration • negative regulation of nitric oxide biosynthetic process • cell adhesion • endothelial cell proliferation • mesangial cell-matrix adhesion • tissue homeostasis • positive regulation of vasculogenesis • endothelium development • regulation of immune response • negative regulation of cellular response to heat • positive regulation of transforming growth factor beta production • glomerular endothelium development • negative regulation of tumor necrosis factor production • cell-matrix adhesion • cell proliferation • positive regulation of odontogenesis • negative regulation of cellular response to hypoxia • leukocyte migration • signal transduction • transdifferentiation • negative regulation of neuron death Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	947	12490
Ensembl	ENSG00000174059	ENSMUSG00000016494
UniProt	P28906	Q64314
RefSeq (mRNA)	NM_001025109 NM_001773	NM_001111059 NM_133654
RefSeq (protein)	NP_001020280 NP_001764	NP_598415.1 NP_001104529 NP_598415
Location (UCSC)	Chr 1: 207.88 – 207.91 Mb	Chr 1: 194.94 – 194.96 Mb
PubMed search

947

12490

ENSG00000174059

ENSMUSG00000016494

P28906

Q64314

NM_001025109
NM_001773

NM_001111059
NM_133654

NP_001020280
NP_001764

NP_598415.1
NP_001104529
NP_598415

Hematopoietic progenitor cell antigen CD34 also known as CD34 antigen is a protein that in humans is encoded by the CD34 gene.

CD34 is a cluster of differentiation first described independently by Civin et al. and Tindle et al. in a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of stem cells to bone marrow extracellular matrix or directly to stromal cells.

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Wikipedia