CD33

Identifiers

CD33, CD33 molecule, SIGLEC-3, SIGLEC3, p67

External IDs

Genetically Related Diseases

Gene ontology
Molecular function	• protein binding • carbohydrate binding • receptor activity
Cellular component	• integral component of membrane • integral component of plasma membrane • extracellular exosome • membrane • external side of plasma membrane • nucleus • plasma membrane • specific granule membrane • tertiary granule membrane
Biological process	• cell-cell signaling • cell adhesion • signal transduction • negative regulation of cell proliferation • regulation of immune response • neutrophil degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


945


n/a

Ensembl


ENSG00000105383


n/a

UniProt


P20138


n/a

RefSeq (mRNA)


NM_001082618 NM_001177608 NM_001772


n/a

RefSeq (protein)


NP_001076087 NP_001171079 NP_001763


n/a

Location (UCSC)

Chr 19: 51.23 – 51.24 Mb

n/a

PubMed search

n/a

945

n/a

ENSG00000105383

n/a

P20138

n/a

NM_001082618
NM_001177608
NM_001772

n/a

NP_001076087
NP_001171079
NP_001763

n/a

CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.

It binds sialic acids, therefore is a member of the SIGLEC family of lectins.

The extracellular portion of this receptor contains two immunoglobulin domains (one IgV and one IgC2 domain), placing CD33 within the immunoglobulin superfamily. The intracellular portion of CD33 contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that are implicated in inhibition of cellular activity.

CD33 is the target of gemtuzumab ozogamicin (trade name: Mylotarg®; Pfizer/Wyeth-Ayerst Laboratories), an Antibody-drug conjugate for the treatment of patients with acute myeloid leukemia. The drug is a recombinant, humanized anti-CD33 monoclonal antibody (IgG4 κ antibody hP67.6) covalently attached to the cytotoxic antitumor antibiotic calicheamicin (N-acetyl-γ-calicheamicin) via a bifunctional linker (4-(4-acetylphenoxy)butanoic acid).

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Wikipedia