CD300LF

CD300LF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NMS
Identifiers
Aliases	CD300LF, CD300f, CLM-1, CLM1, IREM-1, IREM1, IgSF13, LMIR3, NKIR, CD300 molecule like family member f
External IDs	MGI: 2442359 HomoloGene: 51396 GeneCards: CD300LF
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.1 Start 74,694,311 bp End 74,712,978 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E2 Start 115,116,214 bp End 115,133,992 bp
Gene ontology Molecular function • phosphatidylserine binding • interleukin-4 receptor binding • ceramide binding • lipid binding Cellular component • membrane • integral component of membrane • plasma membrane Biological process • immune system process • regulation of immune response • negative regulation of mast cell activation • negative regulation of MyD88-dependent toll-like receptor signaling pathway • TRIF-dependent toll-like receptor signaling pathway • interleukin-13-mediated signaling pathway • positive regulation of interleukin-4-mediated signaling pathway • negative regulation of apoptotic cell clearance • positive regulation of apoptotic cell clearance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	146722	246746
Ensembl	ENSG00000186074	ENSMUSG00000047798
UniProt	Q8TDQ1	Q6SJQ7
RefSeq (mRNA)	NM_001289082 NM_001289083 NM_001289084 NM_001289085 NM_001289086 NM_001289087 NM_139018	NM_001169153 NM_145634 NM_001347648
RefSeq (protein)	NP_001276011 NP_001276012 NP_001276013 NP_001276014 NP_001276015 NP_001276016 NP_620587	NP_001162624 NP_001334577 NP_663609
Location (UCSC)	Chr 17: 74.69 – 74.71 Mb	Chr 17: 115.12 – 115.13 Mb
PubMed search

2NMS

146722

246746

ENSG00000186074

ENSMUSG00000047798

Q8TDQ1

Q6SJQ7

NM_001289087
NM_139018

NM_001169153
NM_145634
NM_001347648

NP_001276016
NP_620587

NP_001162624
NP_001334577
NP_663609

CMRF35-like molecule 1 is a protein that in humans is encoded by the CD300LF gene.

CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. It mediates negative regulatory signals by recruiting SHP1 (PTPN6; MIM 176883) or SHIP (INPP5D; MIM 601582) (Sui et al., 2004; Alvarez-Errico et al., 2004).[supplied by OMIM]

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