CD27

CD27
Identifiers
Aliases	CD27, S152, S152. LPFS2, T14, TNFRSF7, Tp55, CD27 molecule
External IDs	OMIM: 186711 MGI: 88326 HomoloGene: 74386 GeneCards: CD27
Gene ontology Molecular function • tumor necrosis factor-activated receptor activity • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • protein binding • transmembrane signaling receptor activity Cellular component • extracellular exosome • extracellular region • integral component of membrane • integral component of plasma membrane • membrane • cell surface • plasma membrane • external side of plasma membrane • intracellular Biological process • release of cytoplasmic sequestered NF-kappaB • negative regulation of apoptotic process • response to lipopolysaccharide • response to ethanol • negative regulation of T cell apoptotic process • extrinsic apoptotic signaling pathway • regulation of cell proliferation • cell surface receptor signaling pathway • apoptotic process • tumor necrosis factor-mediated signaling pathway • immunoglobulin mediated immune response • positive regulation of JNK cascade • inflammatory response • immune response • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of B cell differentiation • positive regulation of T cell differentiation • multicellular organism development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	939	21940
Ensembl	ENSG00000139193	ENSMUSG00000030336
UniProt	P26842	P41272
RefSeq (mRNA)	NM_001242	NM_001033126 NM_001042564 NM_001286753
RefSeq (protein)	NP_001233	NP_001028298.1 NP_001028298 NP_001036029 NP_001273682
Location (UCSC)	Chr 12: 6.44 – 6.45 Mb	Chr 6: 125.23 – 125.24 Mb
PubMed search

939

21940

ENSG00000139193

ENSMUSG00000030336

P26842

P41272

NM_001242

NM_001033126
NM_001042564
NM_001286753

NP_001233

NP_001028298.1
NP_001028298
NP_001036029
NP_001273682

CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule.

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.

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Wikipedia