CD25

IL2RA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z92, 2B5I, 2ERJ, 3IU3, 3NFP
Identifiers
Aliases	IL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
External IDs	MGI: 96549 HomoloGene: 360 GeneCards: IL2RA
Genetically Related Diseases
rheumatoid arthritis, type 1 diabetes mellitus, multiple sclerosis, Crohn's disease, alopecia areata
Gene ontology Molecular function • interleukin-2 binding • drug binding • Ras guanyl-nucleotide exchange factor activity • interleukin-2 receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • cell surface • external side of plasma membrane • intracellular Biological process • Notch signaling pathway • positive regulation of T cell differentiation • regulation of T cell tolerance induction • inflammatory response to antigenic stimulus • negative regulation of defense response to virus • immune system process • activation-induced cell death of T cells • negative regulation of lymphocyte proliferation • MAPK cascade • T cell homeostasis • regulation of T cell homeostatic proliferation • cell surface receptor signaling pathway • negative regulation of T cell proliferation • negative regulation of immune response • immune response • interleukin-2-mediated signaling pathway • positive regulation of T cell proliferation • cell proliferation • inflammatory response • negative regulation of inflammatory response • positive regulation of activated T cell proliferation • apoptotic process • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3559	16184
Ensembl	ENSG00000134460	ENSMUSG00000026770
UniProt	P01589	P01590
RefSeq (mRNA)	NM_000417 NM_001308242 NM_001308243	NM_008367
RefSeq (protein)	NP_000408 NP_001295171 NP_001295172	NP_032393.3 NP_032393
Location (UCSC)	Chr 10: 6.01 – 6.06 Mb	Chr 2: 11.64 – 11.69 Mb
PubMed search

1Z92, 2B5I, 2ERJ, 3IU3, 3NFP

3559

16184

ENSG00000134460

ENSMUSG00000026770

P01589

P01590

NM_000417
NM_001308242
NM_001308243

NM_008367

NP_000408
NP_001295171
NP_001295172

NP_032393.3
NP_032393

Interleukin-2 receptor alpha chain (also called CD25) is a protein that in humans is encoded by the IL2RA gene.

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