CD226

CD226
Identifiers
Aliases	CD226, DNAM-1, DNAM1, PTA1, TLiSA1, CD226 molecule
External IDs	MGI: 3039602 HomoloGene: 4787 GeneCards: CD226
Gene location (Human) Chr. Chromosome 18 (human) Band 18q22.2 Start 69,831,158 bp End 69,961,803 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 E4 Start 89,197,431 bp End 89,270,201 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein homodimerization activity • protein binding • protein kinase binding • integrin binding • receptor activity • cell adhesion molecule binding Cellular component • cell-cell adherens junction • integral component of plasma membrane • membrane raft • integral component of membrane • membrane • cell surface • external side of plasma membrane • plasma membrane Biological process • positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target • cell adhesion • regulation of immune response • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • homophilic cell adhesion via plasma membrane adhesion molecules • positive regulation of Fc receptor mediated stimulatory signaling pathway • cell recognition • cytokine production • positive regulation of immunoglobulin mediated immune response • signal transduction • positive regulation of natural killer cell mediated cytotoxicity • positive regulation of mast cell activation • positive regulation of interferon-gamma production • positive regulation of natural killer cell cytokine production • positive regulation of T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10666	225825
Ensembl	ENSG00000150637	ENSMUSG00000034028
UniProt	Q15762	Q8K4F0
RefSeq (mRNA)	NM_001303618 NM_001303619 NM_006566	NM_001039148 NM_001039149 NM_178687
RefSeq (protein)	NP_001290547 NP_001290548 NP_006557	NP_001034238 NP_848802
Location (UCSC)	Chr 18: 69.83 – 69.96 Mb	Chr 18: 89.2 – 89.27 Mb
PubMed search

10666

225825

ENSG00000150637

ENSMUSG00000034028

Q15762

Q8K4F0

NM_001303618
NM_001303619
NM_006566

NM_001039148
NM_001039149
NM_178687

NP_001290547
NP_001290548
NP_006557

NP_001034238
NP_848802

CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1') or DNAM-1 (DNAX Accessory Molecule-1) is a protein that in humans is encoded by the CD226 gene which is located on chromosome 18q22.3.

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Wikipedia