CD21

CR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GHQ, 1LY2, 1W2R, 1W2S, 2GSX, 3OED
Identifiers
Aliases	CR2, C3DR, CD21, CR, CVID7, SLEB9, complement component 3d receptor 2, complement C3d receptor 2
External IDs	MGI: 88489 HomoloGene: 55611 GeneCards: CR2
Gene ontology Molecular function • DNA binding • protein homodimerization activity • virus receptor activity • complement binding • transmembrane signaling receptor activity • complement receptor activity Cellular component • integral component of membrane • membrane • receptor complex • extracellular exosome • plasma membrane Biological process • immune system process • B cell proliferation • immune response • complement activation, classical pathway • viral entry into host cell • B cell differentiation • innate immune response • viral process • complement receptor mediated signaling pathway • signal transduction • regulation of complement activation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1380	12902
Ensembl	ENSG00000117322	ENSMUSG00000026616
UniProt	P20023	P19070
RefSeq (mRNA)	NM_001006658 NM_001877	NM_007758
RefSeq (protein)	NP_001006659 NP_001868	n/a
Location (UCSC)	Chr 1: 207.45 – 207.49 Mb	Chr 1: 195.14 – 195.18 Mb
PubMed search

1GHQ, 1LY2, 1W2R, 1W2S, 2GSX, 3OED

1380

12902

ENSG00000117322

ENSMUSG00000026616

P20023

P19070

NM_001006658
NM_001877

NM_007758

NP_001006659
NP_001868

n/a

Complement receptor type 2 (CR2), also known as complement C3d receptor, Epstein-Barr virus receptor, and CD21 (cluster of differentiation 21), is a protein that in humans is encoded by the CR2 gene.

CR2 is involved in the complement system. It binds to iC3b (inactive derivative of C3b), C3dg, or C3d.B cells have CR2 receptors on their surfaces, allowing the complement system to play a role in B-cell activation and maturation

...
Wikipedia