CD133

PROM1
Identifiers
Aliases	PROM1, AC133, CD133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4, prominin 1
External IDs	OMIM: 604365 MGI: 1100886 HomoloGene: 4390 GeneCards: PROM1
Gene ontology Molecular function • actinin binding • cadherin binding • protein binding Cellular component • integral component of membrane • vesicle • cell projection • membrane • plasma membrane • photoreceptor outer segment • integral component of plasma membrane • cilium • cell surface • apical plasma membrane • endoplasmic reticulum • photoreceptor outer segment membrane • extracellular exosome • microvillus membrane • endoplasmic reticulum-Golgi intermediate compartment • extracellular space Biological process • retina layer formation • camera-type eye photoreceptor cell differentiation • retina morphogenesis in camera-type eye • glomerular parietal epithelial cell differentiation • glomerular visceral epithelial cell differentiation • photoreceptor cell maintenance • positive regulation of nephron tubule epithelial cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8842	19126
Ensembl	ENSG00000007062	ENSMUSG00000029086
UniProt	O43490	O54990
RefSeq (mRNA)	NM_001145847 NM_001145848 NM_001145849 NM_001145850 NM_001145851 NM_001145852 NM_006017	NM_001163577 NM_001163578 NM_001163581 NM_001163582 NM_001163583 NM_001163584 NM_001163585 NM_008935
RefSeq (protein)	NP_001139319 NP_001139320 NP_001139321 NP_001139322 NP_001139323 NP_001139324 NP_006008	NP_001157050.1 NP_001157053.1 NP_001157054.1 NP_001157055.1 NP_001157049 NP_001157050 NP_001157053 NP_001157054 NP_001157055 NP_001157056 NP_001157057 NP_032961
Location (UCSC)	Chr 4: 15.96 – 16.08 Mb	Chr 5: 43.99 – 44.1 Mb
PubMed search

8842

19126

ENSG00000007062

ENSMUSG00000029086

O43490

O54990

NM_001145852
NM_006017

NM_001163584
NM_001163585
NM_008935

NP_001139324
NP_006008

NP_001157050
NP_001157053
NP_001157054
NP_001157055
NP_001157056
NP_001157057
NP_032961

CD133 antigen also known as prominin-1 is a glycoprotein that in humans is encoded by the PROM1 gene. It is a member of pentaspan transmembrane glycoproteins (5-transmembrane, 5-TM), which specifically localize to cellular protrusions. While the precise function of CD133 remains unknown, it has been proposed to act as an organizer of cell membrane topology.

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Wikipedia