CCR6

CCR6
Identifiers
Aliases	CCR6, BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22, C-C motif chemokine receptor 6
External IDs	MGI: 1333797 HomoloGene: 3214 GeneCards: CCR6
Gene location (Human) Chr. Chromosome 6 (human) Band 6q27 Start 167,111,807 bp End 167,139,696 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 A1 Start 8,236,043 bp End 8,257,127 bp
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • chemokine receptor activity • receptor activity • protein binding • C-C chemokine receptor activity • C-C chemokine binding Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • intracellular • cell surface • sperm midpiece • sperm flagellum • sperm principal piece • sperm plasma membrane Biological process • movement of cell or subcellular component • positive regulation of cytosolic calcium ion concentration • positive regulation of epithelial cell migration • dendritic cell chemotaxis • cellular defense response • humoral immune response • immune response • positive regulation of dendritic cell chemotaxis • signal transduction • calcium-mediated signaling • chemotaxis • cell chemotaxis • chemokine-mediated signaling pathway • leukocyte migration involved in inflammatory response • isotype switching to IgA isotypes • positive regulation of flagellated sperm motility involved in capacitation • lymphocyte migration • T cell migration • thymocyte migration • DN2 thymocyte differentiation • DN3 thymocyte differentiation • regulation of T cell migration • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1235	12458
Ensembl	ENSG00000112486	ENSMUSG00000040899
UniProt	P51684	O54689
RefSeq (mRNA)	NM_031409 NM_004367	NM_001190333 NM_001190334 NM_001190335 NM_001190336 NM_001190337 NM_001190338 NM_009835
RefSeq (protein)	NP_004358 NP_113597	NP_001177262 NP_001177263 NP_001177264 NP_001177265 NP_001177266 NP_001177267 NP_033965
Location (UCSC)	Chr 6: 167.11 – 167.14 Mb	Chr 6: 8.24 – 8.26 Mb
PubMed search

1235

12458

ENSG00000112486

ENSMUSG00000040899

P51684

O54689

NM_031409
NM_004367

NM_001190338
NM_009835

NP_004358
NP_113597

NP_001177267
NP_033965

Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene. CCR6 has also recently been designated CD196 (cluster of differentiation 196).

This protein belongs to family A of G protein-coupled receptor superfamily. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dendritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.

...
Wikipedia