CCL8

CCL8
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1ESR
Identifiers
Aliases	CCL8, HC14, MCP-2, MCP2, SCYA10, SCYA8, C-C motif chemokine ligand 8
External IDs	OMIM: 602283 HomoloGene: 48362 GeneCards: CCL8
Gene ontology Molecular function • protein kinase activity • cytokine activity • heparin binding • phospholipase activator activity • CCR chemokine receptor binding • chemokine activity Cellular component • extracellular region • cell • extracellular space Biological process • G-protein coupled receptor signaling pathway • monocyte chemotaxis • chemokine-mediated signaling pathway • cellular response to tumor necrosis factor • cell-cell signaling • response to virus • cellular calcium ion homeostasis • neutrophil chemotaxis • chemotaxis • positive regulation of GTPase activity • cellular response to interleukin-1 • immune response • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • lymphocyte chemotaxis • inflammatory response • calcium ion transport • signal transduction • exocytosis • protein phosphorylation • killing of cells of other organism • antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6355	n/a
Ensembl	ENSG00000108700	n/a
UniProt	P80075	n/a
RefSeq (mRNA)	NM_005623	n/a
RefSeq (protein)	NP_005614	n/a
Location (UCSC)	Chr 17: 34.32 – 34.32 Mb	n/a
PubMed search		n/a

1ESR

6355

n/a

ENSG00000108700

n/a

P80075

n/a

NM_005623

n/a

NP_005614

n/a

Chemokine (C-C motif) ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP2), is a protein that in humans is encoded by the CCL8 gene.

CCL8 is a small cytokine belonging to the CC chemokine family. The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans. MCP-2 is chemotactic for and activates many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B and CCR5.

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