CCL21

CCL21
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L4N
Identifiers
Aliases	CCL21, 6Ckine, CKb9, ECL, SCYA21, SLC, TCA4, C-C motif chemokine ligand 21
External IDs	OMIM: 602737 HomoloGene: 2247 GeneCards: CCL21
Gene ontology Molecular function • cytokine activity • chemokine receptor binding • CCR7 chemokine receptor binding • chemokine activity • CCR chemokine receptor binding Cellular component • extracellular region • cell • extracellular space Biological process • negative regulation of leukocyte tethering or rolling • G-protein coupled receptor signaling pathway • release of sequestered calcium ion into cytosol • positive regulation of receptor-mediated endocytosis • positive regulation of protein kinase B signaling • positive regulation of cell motility • positive regulation of actin filament polymerization • monocyte chemotaxis • activation of GTPase activity • ruffle organization • positive regulation of cell-matrix adhesion • chemokine-mediated signaling pathway • cellular response to tumor necrosis factor • cell-cell signaling • T cell costimulation • cell maturation • positive regulation of JNK cascade • dendritic cell chemotaxis • negative regulation of dendritic cell dendrite assembly • positive regulation of phosphatidylinositol 3-kinase activity • chemotaxis • response to prostaglandin E • positive regulation of dendritic cell antigen processing and presentation • dendritic cell dendrite assembly • positive regulation of pseudopodium assembly • mesangial cell-matrix adhesion • positive regulation of chemotaxis • cellular response to interleukin-1 • immune response • establishment of T cell polarity • positive regulation of ERK1 and ERK2 cascade • positive regulation of glycoprotein biosynthetic process • cellular response to interferon-gamma • positive regulation of I-kappaB kinase/NF-kappaB signaling • cell chemotaxis • lymphocyte chemotaxis • positive regulation of neutrophil chemotaxis • negative regulation of leukocyte apoptotic process • positive regulation of cell adhesion mediated by integrin • immunological synapse formation • positive regulation of filopodium assembly • positive regulation of T cell migration • positive regulation of myeloid dendritic cell chemotaxis • positive regulation of protein kinase activity • inflammatory response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6366	100041504
Ensembl	ENSG00000137077	n/a
UniProt	O00585	P86792
RefSeq (mRNA)	NM_002989	XM_001473258
RefSeq (protein)	NP_002980	NP_001180595.1 NP_001180597.1 NP_001257289.1 NP_035465.2 NP_075539.1
Location (UCSC)	Chr 9: 34.71 – 34.71 Mb	Chr 4: 41.9 – 41.9 Mb
PubMed search

2L4N

6366

100041504

ENSG00000137077

n/a

O00585

P86792

NM_002989

XM_001473258

NP_002980

NP_001180595.1
NP_001180597.1
NP_001257289.1
NP_035465.2
NP_075539.1

Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC). The gene for CCL21 is located on human chromosome 9. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7.

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