CALHM1

CALHM1
Identifiers
Aliases	CALHM1, FAM26C, calcium homeostasis modulator 1
External IDs	MGI: 3643383 HomoloGene: 55508 GeneCards: CALHM1
Gene ontology Molecular function • voltage-gated calcium channel activity • calcium activated cation channel activity • calcium channel activity • voltage-gated ion channel activity • identical protein binding Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • plasma membrane • integral component of plasma membrane • endoplasmic reticulum Biological process • sensory perception of umami taste • ATP transport • regulation of ion transmembrane transport • cation transport • ion transport • sensory perception of bitter taste • calcium ion transmembrane transport • transport • sensory perception of sweet taste • protein homooligomerization • sensory perception of taste • calcium ion transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	255022	546729
Ensembl	ENSG00000185933	ENSMUSG00000079258
UniProt	Q8IU99	D3Z291
RefSeq (mRNA)	NM_001001412	NM_001081271
RefSeq (protein)	NP_001001412	NP_001074740.1 NP_001074740
Location (UCSC)	Chr 10: 103.45 – 103.46 Mb	Chr 19: 47.14 – 47.14 Mb
PubMed search

255022

546729

ENSG00000185933

ENSMUSG00000079258

Q8IU99

D3Z291

NM_001001412

NM_001081271

NP_001001412

NP_001074740.1
NP_001074740

Calcium homeostasis modulator 1 (CALHM1) is a pore-forming subunit of a voltage-gated ion channel that in humans is encoded by the CALHM1 gene.

CALHM1 was identified by a tissue-specific gene expression profiling approach that screened for genes located on susceptibility loci for late-onset Alzheimer's disease (AD) and that are preferentially expressed in the hippocampus, a brain region affected early in AD. CALHM1 is a plasma membrane calcium-permeable ion channel regulated by voltage and extracellular calcium levels. The exact function of CALHM1 in the brain is not completely understood, but studies have shown that CALHM1 controls neuronal intracellular calcium homeostasis and signaling, as well as calcium-dependent neuronal excitability and memory in mouse models. Recent data have also shown that CALHM1 might facilitate the proteolytic degradation of the cerebral amyloid beta peptide, a culprit in AD pathogenesis.

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Wikipedia