CACNA1I

CACNA1I
Identifiers
Aliases	CACNA1I, Cav3.3, ca(v)3.3, calcium voltage-gated channel subunit alpha1 I
External IDs	MGI: 2178051 HomoloGene: 69331 GeneCards: CACNA1I
Targeted by Drug
anandamide, mibefradil, pimozide
Gene ontology Molecular function • voltage-gated calcium channel activity • calcium channel activity • low voltage-gated calcium channel activity • voltage-gated ion channel activity • ion channel activity • protein binding • voltage-gated sodium channel activity Cellular component • voltage-gated calcium channel complex • integral component of membrane • membrane • plasma membrane Biological process • flagellated sperm motility • membrane depolarization during action potential • calcium ion import • regulation of ion transmembrane transport • ion transport • positive regulation of calcium ion-dependent exocytosis • sleep • calcium ion transmembrane transport • transmembrane transport • transport • calcium ion transport • signal transduction • neuronal action potential • sodium ion transmembrane transport • regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8911	239556
Ensembl	ENSG00000100346	ENSMUSG00000022416
UniProt	Q9P0X4	n/a
RefSeq (mRNA)	NM_001003406 NM_021096	NM_001044308
RefSeq (protein)	NP_001003406 NP_066919	n/a
Location (UCSC)	Chr 22: 39.57 – 39.69 Mb	Chr 15: 80.29 – 80.4 Mb
PubMed search

8911

239556

ENSG00000100346

ENSMUSG00000022416

Q9P0X4

n/a

NM_001003406
NM_021096

NM_001044308

NP_001003406
NP_066919

n/a

Calcium channel, voltage-dependent, T type, alpha 1I subunit, also known as CACNA1I or Ca_v3.3 is a protein which in humans is encoded by the CACNA1I gene.

Voltage-dependent calcium channels can be distinguished based on their voltage-dependence, deactivation, and single-channel conductance. Low-voltage-activated calcium channels are referred to as 'T' type because their currents are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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