CACNA1H

CACNA1H
Identifiers
Aliases	CACNA1H, CACNA1HB, Cav3.2, ECA6, EIG6, calcium voltage-gated channel subunit alpha1 H
External IDs	MGI: 1928842 HomoloGene: 56913 GeneCards: CACNA1H
Gene ontology Molecular function • voltage-gated calcium channel activity • calcium channel activity • low voltage-gated calcium channel activity • scaffold protein binding • metal ion binding • voltage-gated ion channel activity • ion channel activity • voltage-gated sodium channel activity Cellular component • voltage-gated calcium channel complex • integral component of membrane • membrane • plasma membrane Biological process • muscle contraction • membrane depolarization during action potential • regulation of heart contraction • calcium ion import • aldosterone biosynthetic process • regulation of membrane potential • regulation of ion transmembrane transport • muscle organ development • cortisol biosynthetic process • ion transport • positive regulation of acrosome reaction • cellular response to hormone stimulus • calcium ion transmembrane transport • transmembrane transport • transport • myoblast fusion • cellular response to potassium ion • calcium ion transport • neuronal action potential • positive regulation of calcium ion-dependent exocytosis • regulation of postsynaptic membrane potential • ion transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8912	58226
Ensembl	ENSG00000196557	ENSMUSG00000024112
UniProt	O95180	O88427
RefSeq (mRNA)	NM_001005407 NM_021098	NM_001163691 NM_021415
RefSeq (protein)	NP_001005407 NP_066921	n/a
Location (UCSC)	Chr 16: 1.15 – 1.22 Mb	Chr 17: 25.37 – 25.43 Mb
PubMed search

8912

58226

ENSG00000196557

ENSMUSG00000024112

O95180

O88427

NM_001005407
NM_021098

NM_001163691
NM_021415

NP_001005407
NP_066921

n/a

Calcium channel, voltage-dependent, T type, alpha 1H subunit, also known as CACNA1H, is a protein which in humans is encoded by the CACNA1H gene.

This gene encodes Ca_v3.2, a T-type member of the α₁ subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of α₁, α₂δ, β, and γ subunits in a 1:1:1:1 ratio. The α₁ subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here.

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Wikipedia