CABIN1

CABIN1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1N6J
Identifiers
Aliases	CABIN1, CAIN, PPP3IN, KB-318B8.7, calcineurin binding protein 1
External IDs	MGI: 1298375 HomoloGene: 49307 GeneCards: CABIN1
Gene ontology Molecular function • protein phosphatase inhibitor activity • nucleosome binding Cellular component • aggresome • nucleus • nucleoplasm • cytosol Biological process • DNA replication-independent nucleosome assembly • cell surface receptor signaling pathway • negative regulation of catalytic activity • covalent chromatin modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23523	104248
Ensembl	n/a	ENSMUSG00000020196
UniProt	Q9Y6J0	n/a
RefSeq (mRNA)	NM_001199281 NM_001201429 NM_012295	NM_172549
RefSeq (protein)	NP_001186210 NP_001188358 NP_036427	n/a
Location (UCSC)	Chr 22: 24.01 – 24.18 Mb	Chr 10: 75.65 – 75.76 Mb
PubMed search

1N6J

23523

104248

n/a

ENSMUSG00000020196

Q9Y6J0

n/a

NM_001199281
NM_001201429
NM_012295

NM_172549

NP_001186210
NP_001188358
NP_036427

n/a

Calcineurin-binding protein cabin-1 is a protein that in humans is encoded by the CABIN1 gene.

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. At least four alternatively spliced transcripts have been found for this gene, but the full-length nature of most of them has not been determined.

CABIN1 has been shown to interact with:

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