C3a receptor

C3AR1
Identifiers
Aliases	C3AR1, AZ3B, C3AR, HNFAG09, complement component 3a receptor 1, complement C3a receptor 1
External IDs	OMIM: 605246 MGI: 1097680 HomoloGene: 2992 GeneCards: C3AR1
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.31 Start 8,058,302 bp End 8,066,471 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 F2 Start 122,847,138 bp End 122,856,161 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • signal transducer activity • G-protein coupled receptor activity • complement receptor activity • complement component C3a receptor activity Cellular component • integral component of membrane • integral component of plasma membrane • membrane • plasma membrane • azurophil granule membrane • specific granule membrane Biological process • blood circulation • signal transduction • complement receptor mediated signaling pathway • chemotaxis • positive regulation of neutrophil chemotaxis • positive regulation of angiogenesis • positive regulation of macrophage chemotaxis • inflammatory response • positive regulation of vascular endothelial growth factor production • G-protein coupled receptor signaling pathway • regulation of complement activation • positive regulation of cytosolic calcium ion concentration • phospholipase C-activating G-protein coupled receptor signaling pathway • neutrophil degranulation • leukocyte migration • cell chemotaxis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	719	12267
Ensembl	ENSG00000171860	ENSMUSG00000040552
UniProt	Q16581	O09047
RefSeq (mRNA)	NM_004054 NM_001326475 NM_001326477	NM_009779
RefSeq (protein)	NP_001313404 NP_001313406 NP_004045	NP_033909
Location (UCSC)	Chr 12: 8.06 – 8.07 Mb	Chr 12: 122.85 – 122.86 Mb
PubMed search

719

12267

ENSG00000171860

ENSMUSG00000040552

Q16581

O09047

NM_004054
NM_001326475
NM_001326477

NM_009779

NP_001313404
NP_001313406
NP_004045

NP_033909

The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system.

The receptor binds to complement component C3a, although there is limited evidence that this receptor also binds C4a in lesser mammals this has yet to be proven true in humans. C3a receptor modulates immunity, arthritis, diet-induced obesity and cancers

Potent and selective agonists and antagonists for C3aR have been discovered.

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Wikipedia