C1r

C1R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1APQ, 1GPZ, 1MD7, 1MD8, 2QY0
Identifiers
Aliases	C1R, complement C1r, EDSPD1
External IDs	MGI: 1355313 HomoloGene: 1313 GeneCards: C1R
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.31 Start 7,080,209 bp End 7,092,607 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 F2 Start 124,512,405 bp End 124,523,443 bp
Gene ontology Molecular function • peptidase activity • serine-type peptidase activity • serine-type endopeptidase activity • protein binding • hydrolase activity • calcium ion binding Cellular component • extracellular region • blood microparticle • extracellular exosome • extracellular space Biological process • immune response • proteolysis • complement activation, classical pathway • immune system process • innate immune response • complement activation • regulation of complement activation • zymogen activation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	715	50909
Ensembl	ENSG00000159403	ENSMUSG00000055172
UniProt	P00736	Q8CG16
RefSeq (mRNA)	NM_001733 NM_001354346	NM_023143
RefSeq (protein)	NP_001724 NP_001341275	NP_075632
Location (UCSC)	Chr 12: 7.08 – 7.09 Mb	Chr 12: 124.51 – 124.52 Mb
PubMed search

1APQ, 1GPZ, 1MD7, 1MD8, 2QY0

715

50909

ENSG00000159403

ENSMUSG00000055172

P00736

Q8CG16

NM_001733
NM_001354346

NM_023143

NP_001724
NP_001341275

NP_075632

Complement C1r subcomponent (EC 3.4.21.41, activated complement C1r, C overbar 1r esterase, C1r) is a protein involved in the complement system of the innate immune system. In humans, C1r is encoded by the C1R gene.

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