C1orf131

Uncharacterized protein C1orf131 is a protein that in humans is encoded by the gene C1orf131. The first ortholog of this protein was discovered in humans. Subsequently, through the use of algorithms and bioinformatics, homologs of C1orf131 have been discovered in numerous species, and as a result, the name of the majority of the proteins in this protein family is Uncharacterized protein C1orf131 homolog.

In humans C1orf131 is located on the minus strand of chromosome 1 and on the cytogenetic band 1q42.2 along with 193 other genes. Notably, the gene upstream of C1orf131 is GNPAT, and the gene downstream of C1orf131 is TRIM67. When this gene is transcribed in humans, C1orf131 most often forms an mRNA of 1458 base pairs long which is composed of seven exons. There are at least nine others alternative splice forms in humans that produce proteins. They range in size from 129 base pairs (2 exons) to 1458 base pairs (7 exons).

In the C1orf131 protein family, the proteins are between 93 and 450 amino acids long; however, the majority tend to be between 160-295 amino acids long. They have a molecular weight between 10.6 and 49.0 kDa with the majority between 18.6 and 32.7 kDa. They have an isoelectric point between 9.6 and 11.2. Over 30 orthologs from mammals, birds and lizards have been identified as having a poly(A) RNA binding site. All orthologs in this protein family have a domain of unknown function DUF4602. The human protein has been shown to be both phosphorylated and acetylated. These proteins are lysines rich, charged amino acids (DEHKR), and basic charged amino acids (HKR). The secondary structure of these proteins primarily consist of alpha helices and coils with a small percentage of beta strands. C1orf131 has been shown to interact with ubiquitin through affinity capture followed by mass spectrometry and APP (amyloid beta (A4) precursor protein) through reconstituted complex.

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