C10orf54

VSIR
Identifiers
Aliases	VSIR, B7-H5, B7H5, GI24, PP2135, SISP1, DD1alpha, VISTA, C10orf54, chromosome 10 open reading frame 54, PD-1H, V-set immunoregulatory receptor
External IDs	MGI: 1921298 HomoloGene: 81923 GeneCards: VSIR
Gene location (Human) Chr. Chromosome 10 (human) Band 10q22.1 Start 71,747,559 bp End 71,773,498 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 B4 Start 60,346,851 bp End 60,372,684 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • identical protein binding Cellular component • integral component of membrane • membrane • plasma membrane Biological process • single organismal cell-cell adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64115	74048
Ensembl	ENSG00000107738	ENSMUSG00000020101
UniProt	Q9H7M9	Q9D659
RefSeq (mRNA)	NM_022153	NM_001159572 NM_028732
RefSeq (protein)	NP_071436	NP_001153044 NP_083008
Location (UCSC)	Chr 10: 71.75 – 71.77 Mb	Chr 10: 60.35 – 60.37 Mb
PubMed search

64115

74048

ENSG00000107738

ENSMUSG00000020101

Q9H7M9

Q9D659

NM_022153

NM_001159572
NM_028732

NP_071436

NP_001153044
NP_083008

V-domain Ig suppressor of T cell activation (VISTA) is a type I transmembrane protein that functions as an immune checkpoint and is encoded by the C10orf54 gene.

VISTA is approximately 50kDa and belongs to the immunoglobulin superfamily and has one IgV domain.

VISTA is part of the B7 family, is primarily expressed in white blood cells and its transcription is partially controlled by p53. There is evidence that VISTA can act as both a ligand and a receptor on T cells to inhibit T cell effector function and maintain peripheral tolerance.

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Wikipedia