C-type natriuretic peptide

NPPC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JDP
Identifiers
Aliases	NPPC, CNP, CNP2, Natriuretic peptide precursor C, natriuretic peptide C
External IDs	MGI: 97369 HomoloGene: 7867 GeneCards: NPPC
Gene ontology Molecular function • protein homodimerization activity • hormone activity • peptide hormone receptor binding • receptor binding Cellular component • secretory granule • extracellular region • extracellular space • protein complex Biological process • animal organ development • negative regulation of meiotic cell cycle • regulation of cardiac conduction • growth plate cartilage chondrocyte proliferation • regulation of blood vessel size • response to hypoxia • regulation of cGMP metabolic process • ossification • regulation of multicellular organism growth • negative regulation of oocyte maturation • growth plate cartilage chondrocyte differentiation • single organism reproductive process • positive regulation of cGMP biosynthetic process • post-embryonic development • receptor guanylyl cyclase signaling pathway • regulation of smooth muscle cell proliferation • cGMP biosynthetic process • positive regulation of osteoblast differentiation • regulation of cAMP metabolic process • negative regulation of DNA metabolic process • response to ethanol • response to drug • negative regulation of cell proliferation • protein folding • positive regulation of blood vessel diameter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4880	18159
Ensembl	ENSG00000163273	ENSMUSG00000026241
UniProt	P23582	Q61839
RefSeq (mRNA)	NM_024409	NM_010933
RefSeq (protein)	NP_077720	NP_035063.1 NP_035063
Location (UCSC)	Chr 2: 231.92 – 231.93 Mb	Chr 1: 86.67 – 86.67 Mb
PubMed search

1JDP

4880

18159

ENSG00000163273

ENSMUSG00000026241

P23582

Q61839

NM_024409

NM_010933

NP_077720

NP_035063.1
NP_035063

Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene. The precursor NPPC protein is cleaved to the 22 amino acid peptide C-type natriuretic peptide (CNP).

Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control. Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective agonist for the B-type natriuretic receptor (NPRB) whereas ANP and BNP are selective for the A-type natriuretic receptor (NPRA).

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