Brenner tumour

Brenner tumor
A Brenner tumor of ovary (gross image).
Classification and external resources
ICD-9-CM	220
ICD-O	9000
DiseasesDB	33431
MeSH	D001948
[]

Brenner tumors are an uncommon subtype of the surface epithelial-stromal tumor group of ovarian neoplasms. The majority are benign, but some can be malignant.

They are most frequently found incidentally on pelvic examination or at laparotomy. Brenner tumours very rarely can occur in other locations, including the testes.

On gross pathological examination, they are solid, sharply circumscribed and pale yellow-tan in colour. 90% are unilateral (arising in one ovary, the other is unaffected). The tumours can vary in size from less than 1 centimetre (0.39 in) to 30 centimetres (12 in). Borderline and malignant Brenner tumours are possible but each are rare.

Histologically, there are nests of transitional epithelial (urothelial) cells with longitudinal nuclear grooves (coffee bean nuclei) lying in abundant fibrous stroma.

Transitional cell carcinoma is an even rarer entity, in which neoplastic transitional epithelial cells similar to transitional cell carcinoma of the bladder are seen in the ovary, without the characteristic stromal/epithelial pattern of a Brenner tumour.

It is named for Fritz Brenner (1877–1969), a German surgeon who characterized it in 1907. The term "Brenner tumor" was first used by Robert Meyer, in 1932.

Micrograph of a Walthard cell nest, the entity Brenner tumours are thought to arise from. H&E stain.

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