Brain-type natriuretic peptide

NPPB
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3N56, 1YK1
Identifiers
Aliases	NPPB, BNP, natriuretic peptide B
External IDs	OMIM: 600295 HomoloGene: 81698 GeneCards: NPPB
Gene ontology Molecular function • receptor binding • protein binding • diuretic hormone activity • hormone activity Cellular component • extracellular region • protein complex • extracellular space Biological process • regulation of blood pressure • cGMP biosynthetic process • negative regulation of angiogenesis • cell surface receptor signaling pathway • regulation of vascular permeability • regulation of blood vessel size • receptor guanylyl cyclase signaling pathway • positive regulation of renal sodium excretion • negative regulation of cell growth • positive regulation of urine volume • body fluid secretion • regulation of blood vessel diameter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4879	n/a
Ensembl	ENSG00000120937	n/a
UniProt	P16860	n/a
RefSeq (mRNA)	NM_002521	n/a
RefSeq (protein)	NP_002512	n/a
Location (UCSC)	Chr 1: 11.86 – 11.86 Mb	n/a
PubMed search		n/a

3N56, 1YK1

4879

n/a

ENSG00000120937

n/a

P16860

n/a

NM_002521

n/a

NP_002512

n/a

Brain natriuretic peptide or B-type natriuretic peptide (BNP) (also ventricular natriuretic peptide or natriuretic peptide B) is a 32-amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes). The release of BNP is modulated by calcium ions. BNP is named as such because it was originally identified in extracts of porcine brain, although in humans it is produced mainly in the cardiac ventricles.

BNP is secreted attached to a 76–amino acid N-terminal fragment in the prohormone called NT-proBNP (BNPT), which is biologically inactive. Once released, BNP binds to and activates the atrial natriuretic factor receptors NPRA, and to a lesser extent NPRB, in a fashion similar to atrial natriuretic peptide (ANP) but with 10-fold lower affinity. The biological half-life of BNP, however, is twice as long as that of ANP, and that of NT-proBNP is even longer, making these peptides better targets than ANP for diagnostic blood testing.

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