Brachyury

T
Identifiers
Aliases	T, brachyury homolog (mouse), SAVA, TFT brachyury transcription factor
External IDs	OMIM: 601397 MGI: 98472 HomoloGene: 2393 GeneCards: T
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription factor binding • transcription factor activity, sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II transcription factor binding • RNA polymerase II activating transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding Cellular component • cytoplasm • nuclear chromatin • chromatin • nucleus Biological process • somitogenesis • cellular response to retinoic acid • determination of heart left/right asymmetry • regulation of transcription, DNA-templated • SMAD protein signal transduction • regulation of transcription from RNA polymerase II promoter • neural plate morphogenesis • bone morphogenesis • anatomical structure morphogenesis • heart morphogenesis • notochord development • signal transduction involved in regulation of gene expression • negative regulation of transcription from RNA polymerase II promoter • BMP signaling pathway • transcription, DNA-templated • embryonic skeletal system development • vasculogenesis • multicellular organism development • reproductive process • neural tube closure • positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation • positive regulation of cell proliferation • notochord formation • post-anal tail morphogenesis • canonical Wnt signaling pathway • mesoderm migration involved in gastrulation • mesoderm development • anterior/posterior axis specification, embryo • penetration of zona pellucida • primitive streak formation • signal transduction • anterior/posterior pattern specification • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6862	20997
Ensembl	ENSG00000164458	ENSMUSG00000062327
UniProt	O15178	P20293
RefSeq (mRNA)	NM_001270484 NM_003181	NM_009309
RefSeq (protein)	NP_001257413 NP_003172	NP_033335.1 NP_033335
Location (UCSC)	Chr 6: 166.16 – 166.17 Mb	Chr 17: 8.43 – 8.44 Mb
PubMed search

6862

20997

ENSG00000164458

ENSMUSG00000062327

O15178

P20293

NM_001270484
NM_003181

NM_009309

NP_001257413
NP_003172

NP_033335.1
NP_033335

Brachyury is a protein that in humans is encoded by the T gene. Brachyury is a transcription factor within the T-box complex of genes. It has been found in all bilaterian animals that have been screened, and is also present in the cnidaria.

The brachyury mutation was first described in mice by Nadezhda Alexandrovna Dobrovolskaya-Zavadskaya in 1927 as a mutation that affected tail length and sacral vertebrae in heterozygous animals. In homozygous animals the brachyury mutation is lethal at around embryonic day 10 due to defects in mesoderm formation, differentiation and the absence of structures posterior to the forlimb bud (Dobrovolskaïa-Zavadskaïa, 1927). The name brachyury comes from the Greek brakhus meaning short and oura meaning tail.

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Wikipedia