Bouveault aldehyde synthesis

Bouveault aldehyde synthesis
Named after	Louis Bouveault
Reaction type	Carbon-carbon bond forming reaction
Identifiers
RSC ontology ID	RXNO:0000533

The Bouveault aldehyde synthesis (also known as the Bouveault reaction) is a one-pot substitution reaction that replaces an alkyl or aryl halide with a formyl group using a N,N-disubstituted formamide. For primary alkyl halides this produces the homologous aldehyde one carbon longer. For aryl halides this produces the corresponding carbaldehyde. Bouveault aldehyde synthesis is an example of a formylation reaction.

The first step of the Bouveault aldehyde synthesis is the formation of the Grignard reagent. Upon addition of a N,N-disubstituted formamide (such as DMF) a hemiaminal is formed, which can easily be hydrolyzed into the desired aldehyde .

Variants using organolithium reagents instead of magnesium-based Grignard reagents are also considered Bouveault aldehyde syntheses.

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