Bone morphogenetic protein 4

BMP4
Identifiers
Aliases	BMP4, BMP2B, BMP2B1, MCOPS6, OFC11, ZYME, bone morphogenetic protein 4
External IDs	OMIM: 112262 MGI: 88180 HomoloGene: 7247 GeneCards: BMP4
Gene ontology Molecular function • heparin binding • cytokine activity • co-receptor binding • transforming growth factor beta receptor binding • growth factor activity • BMP receptor binding • protein binding • chemoattractant activity Cellular component • extracellular region • proteinaceous extracellular matrix • extracellular space Biological process • embryonic skeletal system morphogenesis • negative regulation of T cell differentiation in thymus • germ cell development • skeletal system development • mesenchymal cell differentiation involved in renal system development • cardiac septum development • ureteric bud development • positive regulation of protein phosphorylation • renal system process • positive regulation of endothelial cell differentiation • negative regulation of immature T cell proliferation in thymus • bud elongation involved in lung branching • tendon cell differentiation • anatomical structure formation involved in morphogenesis • ureter epithelial cell differentiation • negative regulation of cell cycle • mesenchymal to epithelial transition involved in metanephros morphogenesis • trachea development • post-embryonic development • monocyte differentiation • specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway • blood vessel endothelial cell proliferation involved in sprouting angiogenesis • BMP signaling pathway involved in renal system segmentation • cranial suture morphogenesis • mesonephros development • odontogenesis of dentin-containing tooth • telencephalon regionalization • negative regulation of chondrocyte differentiation • blood vessel development • negative regulation of mitotic nuclear division • angiogenesis • prostate gland morphogenesis • positive regulation of ERK1 and ERK2 cascade • smooth muscle tissue development • BMP signaling pathway involved in heart induction • negative regulation of epithelial cell proliferation • tissue development • metanephric collecting duct development • inner ear receptor cell differentiation • mesodermal cell fate determination • metanephros development • type B pancreatic cell development • regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of cell proliferation • steroid hormone mediated signaling pathway • mammary gland formation • positive regulation of collagen biosynthetic process • renal system development • negative regulation of myoblast differentiation • cell fate commitment • common-partner SMAD protein phosphorylation • glomerular visceral epithelial cell development • SMAD protein signal transduction • ossification • activation of MAPKK activity • kidney development • lung development • ureter smooth muscle cell differentiation • embryonic digit morphogenesis • epithelial-mesenchymal cell signaling • negative regulation of thymocyte apoptotic process • mesenchymal cell differentiation involved in kidney development • negative regulation of cell death • regulation of odontogenesis of dentin-containing tooth • BMP signaling pathway involved in ureter morphogenesis • mesenchymal cell proliferation involved in ureteric bud development • smooth muscle cell differentiation • negative regulation of gene expression • lymphoid progenitor cell differentiation • epithelium development • positive regulation of transcription, DNA-templated • deltoid tuberosity development • negative regulation of prostatic bud formation • heart development • telencephalon development • branching involved in ureteric bud morphogenesis • positive regulation of kidney development • cartilage development • embryonic limb morphogenesis • negative regulation of MAP kinase activity • positive regulation of cartilage development • lens induction in camera-type eye • positive regulation of neuron differentiation • branching involved in prostate gland morphogenesis • regulation of protein import into nucleus • positive regulation of cell differentiation • erythrocyte differentiation • smoothened signaling pathway • camera-type eye development • secondary heart field specification • negative regulation of phosphorylation • regulation of smooth muscle cell differentiation • regulation of cell fate commitment • regulation of branching involved in prostate gland morphogenesis • cell differentiation • positive regulation of branching involved in lung morphogenesis • chondrocyte differentiation • regulation of cartilage development • organ induction • positive regulation of epithelial cell proliferation • epithelial cell proliferation involved in lung morphogenesis • negative regulation of cell proliferation involved in heart morphogenesis • negative regulation of apoptotic process • positive regulation of ossification • endochondral ossification • positive regulation of DNA-dependent DNA replication • regulation of smooth muscle cell proliferation • regulation of morphogenesis of a branching structure • BMP signaling pathway • macrophage differentiation • negative regulation of metanephric comma-shaped body morphogenesis • embryonic skeletal system development • mesenchymal cell proliferation involved in ureter development • osteoblast differentiation • hematopoietic progenitor cell differentiation • positive regulation of BMP signaling pathway • regulation of gene expression • embryonic cranial skeleton morphogenesis • dorsal/ventral neural tube patterning • lung alveolus development • positive regulation of protein binding • anterior/posterior axis specification • negative regulation of transcription, DNA-templated • positive regulation of epidermal cell differentiation • branching morphogenesis of an epithelial tube • trachea formation • specification of animal organ position • negative regulation of glomerular mesangial cell proliferation • positive regulation of smooth muscle cell proliferation • intermediate mesodermal cell differentiation • pulmonary artery endothelial tube morphogenesis • pituitary gland development • positive regulation of cell death • lung morphogenesis • positive regulation of endothelial cell proliferation • bud dilation involved in lung branching • positive regulation of cardiac muscle fiber development • negative regulation of striated muscle tissue development • positive regulation of cell migration • negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway • BMP signaling pathway involved in nephric duct formation • positive regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of mesenchymal cell proliferation involved in ureter development • mesoderm formation • cellular response to growth factor stimulus • glomerular capillary formation • bronchus development • positive regulation of endothelial cell migration • multicellular organism development • negative regulation of metanephric S-shaped body morphogenesis • neural tube closure • vasculature development • positive regulation of gene expression • embryonic morphogenesis • positive regulation of cell proliferation • protein localization to nucleus • positive regulation of apoptotic process • embryonic skeletal joint morphogenesis • regulation of cell differentiation • negative regulation of branching involved in ureteric bud morphogenesis • mesodermal cell differentiation • neuron fate commitment • forebrain development • cloacal septation • bone development • camera-type eye morphogenesis • positive regulation of SMAD protein import into nucleus • negative regulation of glomerulus development • embryonic hindlimb morphogenesis • positive chemotaxis • outflow tract morphogenesis • odontogenesis • negative regulation of transcription from RNA polymerase II promoter • epithelial to mesenchymal transition involved in endocardial cushion formation • cardiac jelly development • cellular response to BMP stimulus • positive regulation of osteoblast differentiation • epithelial tube branching involved in lung morphogenesis • cardiac muscle cell differentiation • apoptotic process involved in endocardial cushion morphogenesis • muscular septum morphogenesis • positive regulation of transcription from RNA polymerase II promoter • positive regulation of bone mineralization • cardiac right ventricle morphogenesis • outflow tract septum morphogenesis • membranous septum morphogenesis • aortic valve morphogenesis • pulmonary valve morphogenesis • endocardial cushion development • endoderm development • coronary vasculature development • BMP signaling pathway involved in heart development • pharyngeal arch artery morphogenesis • positive regulation of cell proliferation involved in outflow tract morphogenesis • negative regulation of extrinsic apoptotic signaling pathway • regulation of pri-miRNA transcription from RNA polymerase II promoter • positive regulation of production of miRNAs involved in gene silencing by miRNA • growth Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	652	12159
Ensembl	ENSG00000125378	ENSMUSG00000021835
UniProt	P12644	P21275
RefSeq (mRNA)	NM_001202 NM_130850 NM_130851	NM_007554 NM_001316360
RefSeq (protein)	NP_001193 NP_570911 NP_001334841 NP_001334842 NP_001334843 NP_001334844 NP_001334845 NP_001334846 NP_570912	NP_001303289.1 NP_031580.2 NP_001303289 NP_031580
Location (UCSC)	Chr 14: 53.95 – 53.96 Mb	Chr 14: 46.38 – 46.39 Mb
PubMed search

652

12159

ENSG00000125378

ENSMUSG00000021835

P12644

P21275

NM_001202
NM_130850
NM_130851

NM_007554
NM_001316360

NP_001334844
NP_001334845
NP_001334846
NP_570912

NP_001303289.1
NP_031580.2
NP_001303289
NP_031580

Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene. BMP4 is found on chromosome 14q22-q23

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