Blay Creek is a stream in St. Francois and Washington counties in the U.S. state of Missouri. It is a tributary of the Big River.
The stream headwaters are at 37°54′46″N 90°41′46″W / 37.91278°N 90.69611°W and its confluence with the Big River is at 37°52′12″N 90°38′20″W / 37.87000°N 90.63889°WCoordinates: 37°52′12″N 90°38′20″W / 37.87000°N 90.63889°W.