Bissonnet Street is an arterial road in Houston, Texas, United States.
Bissonnet serves the southwestern areas in Houston. It passes through the Houston Museum District, City of West University Place, City of Bellaire, and the Gulfton, Sharpstown, and Alief sections of Houston. It is one of Houston's most misspelled streets. Of recent note along the street is the proposed Ashby Highrise, a 21-story apartment building slated for 1717 Bissonnet. The Houston Press ranked Bissonnet as the "Best Route into the City" in its 2007 Awards.
The street is a well known thoroughfare for soliciting prostitution. So much so that in late April and early May 2013 Houston police staged an operation they referred to as the "Bissonnet Initiative" which resulted in the arrest of more than 100 people involved in the sex trade.