Binding immunoglobulin protein

HSPA5

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3IUC, 3LDL, 3LDN, 3LDO, 3LDP, 5E84, 5E86, 5E85, 5F1X, 5EX5, 5EVZ, 5F2R, 5F0X, 5EY4, 5EXW

Identifiers

Aliases

HSPA5, BIP, GRP78, HEL-S-89n, MIF2, Binding immunoglobulin protein, heat shock protein family A (Hsp70) member 5

External IDs

MGI: 95835 HomoloGene: 3908 GeneCards: HSPA5

Gene ontology
Molecular function	• nucleotide binding • calcium ion binding • chaperone binding • protein domain specific binding • ribosome binding • misfolded protein binding • glycoprotein binding • ATPase activity • protein binding • enzyme binding • ATP binding • ubiquitin protein ligase binding • unfolded protein binding • cadherin binding
Cellular component	• cytoplasm • endoplasmic reticulum lumen • endoplasmic reticulum membrane • membrane • focal adhesion • melanosome • myelin sheath • plasma membrane • smooth endoplasmic reticulum • endoplasmic reticulum chaperone complex • cell surface • integral component of endoplasmic reticulum membrane • midbody • endoplasmic reticulum • mitochondrion • COP9 signalosome • extracellular exosome • nucleus • endoplasmic reticulum-Golgi intermediate compartment • extracellular matrix
Biological process	• activation of signaling protein activity involved in unfolded protein response • cellular response to interleukin-4 • regulation of ATF6-mediated unfolded protein response • cellular response to glucose starvation • regulation of protein folding in endoplasmic reticulum • substantia nigra development • positive regulation of cell migration • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress • maintenance of protein localization in endoplasmic reticulum • negative regulation of apoptotic process • protein folding in endoplasmic reticulum • negative regulation of transforming growth factor beta receptor signaling pathway • toxin transport • response to endoplasmic reticulum stress • PERK-mediated unfolded protein response • cerebellum structural organization • ER overload response • endoplasmic reticulum unfolded protein response • ATF6-mediated unfolded protein response • IRE1-mediated unfolded protein response • cerebellar Purkinje cell layer development • regulation of PERK-mediated unfolded protein response • ubiquitin-dependent ERAD pathway • cellular response to antibiotic • negative regulation of protein homodimerization activity • proteolysis involved in cellular protein catabolic process • cellular response to manganese ion • positive regulation of protein ubiquitination • regulation of IRE1-mediated unfolded protein response • response to radiation • positive regulation of neuron projection development • neuron differentiation • cellular response to drug • response to cocaine • neuron apoptotic process • cellular response to calcium ion • cellular response to cAMP • stress response to metal ion • response to methamphetamine hydrochloride • cellular response to nerve growth factor stimulus
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3309


14828

Ensembl


ENSG00000044574


ENSMUSG00000026864

UniProt


P11021


P20029

RefSeq (mRNA)


NM_005347


NM_001163434 NM_022310

RefSeq (protein)


NP_005338


NP_001156906.1 NP_071705.3 NP_001156906 NP_071705

Location (UCSC)

Chr 9: 125.23 – 125.24 Mb

Chr 2: 34.77 – 34.78 Mb

PubMed search

3IUC, 3LDL, 3LDN, 3LDO, 3LDP, 5E84, 5E86, 5E85, 5F1X, 5EX5, 5EVZ, 5F2R, 5F0X, 5EY4, 5EXW

NM_001163434
NM_022310

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