Big Baby (House)

"Big Baby" is the thirteenth episode of the fifth season of House and the ninety-ninth episode overall. It aired on January 26, 2009.

Sarah, a 29-year-old special education teacher, coughs up blood and collapses. ITP (idiopathic thrombocytopenic purpura) and lymphoma are considered. House orders the team to start Sarah on methotrexate for the ITP and also wants to give her total body irradiation.

Cameron has been hired by Cuddy as a temporary replacement. The methotrexate is not working. House therefore has his team double the dose and add prednisone, as well as fake the radiation treatment. While she is being "irradiated", she needs to urinate. When she gets up, she collapses. Thirteen and Taub discover that she has no pulse and defibrillate her.

Meanwhile, Wilson visits Cuddy. Cuddy reveals that she is having trouble bonding with Rachel. Wilson tells her to just give it time. Also, Foreman is troubled by his discovery that Thirteen is on a placebo, and consults with Chase about surreptitiously switching her to the real thing. Chase tells him that this is unwise.

Tests revealed no structural heart defects, and after some deliberations the possibility of cold agglutinin disease is raised. House wants to give the patient an ice bath to confirm, and goes to Cameron again. Cuddy stops by at the hospital. She has found out about Cameron's permissiveness with House and admonishes her. House barges in while the two are talking. He brings up Cuddy's bonding problem, and suggests giving Rachel up. Cuddy leaves, and Cameron tells House to perform a test on a sample of the blood before trying the cold bath. The blood clots when exposed to cold, but when the patient is put in the cold bath, her vital signs remain normal.