Betsy Mix Cowles (February 9, 1810 – July 25, 1876) was an early leader in the United States abolitionist movement. She was an active and influential Ohio-based reformer, and was a noted feminist and an educator. She counted among her friends and acquaintances people such as Frederick Douglass, William Lloyd Garrison, Henry C. Wright, and Abby Kelley Foster.
She was born in Bristol, Connecticut, the eighth child of Giles Hooker Cowles and Sally White Cowles. Cowles did not marry and supported herself as a teacher and school system administrator in Ashtabula County, Ohio, where Cowles and her family settled.
Edwin Cowles, publisher of the Cleveland Leader in Cleveland, Ohio, and Alfred Cowles, Sr. who owned one third of the Chicago Tribune, were sons of her brother Edwin Weed Cowles and Almira Mills Foote.
Betsey Mix Cowles is known for her contributions to education, abolitionism, and women's rights in Ohio. As early as the late 1820s and early 1830s, she and her sister began opening infant schools in northeastern Ohio. Infant schools were a predecessor to kindergartens. After obtaining a degree from Oberlin College in 1840s, Cowles began a formal career as a teacher. She taught at a number of grammar schools, in addition to serving as a principal and evidentially as superintendent of the Painesville, Ohio, school system. It was very unusual to see women superintendents in the mid-19th century.
Even before she began teaching, Cowles was very interested in abolitionism. She became actively involved in a number of abolitionist organizations, often serving in leadership positions. Beginning in 1835, Cowles served as the secretary of the Ashtabula Female Anti-Slavery Society, one of the larger such organizations in the state with more than four hundred members. She began giving public speeches about abolitionism, gaining a reputation for her ability to articulate the importance of the anti-slavery cause. Even former slave and prominent abolitionist Frederick Douglass respected her abilities. In addition to her interests in the state of Ohio, Cowles was becoming prominent at the national level as well. Not everyone approved of her popularity, however. Many people believed that women should not speak in public, and Cowles's speeches left her open to criticism. In spite of this concern, she continued to actively participate in the anti-slavery movement.