Betaglycan

TGFBR3
Identifiers
Aliases	TGFBR3, BGCAN, betaglycan, transforming growth factor beta receptor 3
External IDs	OMIM: 600742 MGI: 104637 HomoloGene: 2436 GeneCards: TGFBR3
Gene location (Human) Chr. Chromosome 1 (human) Band 1p22.1 Start 91,680,343 bp End 91,906,335 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 E5 Start 107,106,570 bp End 107,289,629 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transforming growth factor beta receptor binding • heparin binding • activin binding • transforming growth factor beta receptor activity, type III • transforming growth factor beta-activated receptor activity • SMAD binding • PDZ domain binding • coreceptor activity • fibroblast growth factor binding • type II transforming growth factor beta receptor binding • protein binding • glycosaminoglycan binding • transforming growth factor beta binding Cellular component • extracellular exosome • extracellular region • cytoplasm • integral component of membrane • proteinaceous extracellular matrix • inhibin-betaglycan-ActRII complex • integral component of plasma membrane • membrane • cell surface • receptor complex • plasma membrane • external side of plasma membrane • extracellular space Biological process • response to hypoxia • heart trabecula formation • intracellular signal transduction • liver development • animal organ regeneration • definitive erythrocyte differentiation • BMP signaling pathway • negative regulation of cellular component movement • positive regulation of transforming growth factor beta receptor signaling pathway • regulation of protein binding • heart morphogenesis • transforming growth factor beta receptor complex assembly • cardiac epithelial to mesenchymal transition • pathway-restricted SMAD protein phosphorylation • response to follicle-stimulating hormone • ventricular cardiac muscle tissue morphogenesis • palate development • cardiac muscle cell proliferation • response to prostaglandin E • protein complex assembly • negative regulation of transforming growth factor beta receptor signaling pathway • negative regulation of epithelial cell proliferation • cell migration • definitive hemopoiesis • cell growth • epithelial to mesenchymal transition • response to luteinizing hormone • immune response • transforming growth factor beta receptor signaling pathway • epicardium-derived cardiac fibroblast cell development • ventricular septum morphogenesis • regulation of ERK1 and ERK2 cascade • ventricular compact myocardium morphogenesis • heart trabecula morphogenesis • positive regulation of cardiac muscle cell proliferation • regulation of JNK cascade • muscular septum morphogenesis • vasculogenesis involved in coronary vascular morphogenesis • outflow tract morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7049	21814
Ensembl	ENSG00000069702	ENSMUSG00000029287
UniProt	Q03167	O88393
RefSeq (mRNA)	NM_001195683 NM_001195684 NM_003243	NM_011578
RefSeq (protein)	NP_001182612 NP_001182613 NP_003234	NP_035708
Location (UCSC)	Chr 1: 91.68 – 91.91 Mb	Chr 1: 107.11 – 107.29 Mb
PubMed search

7049

21814

ENSG00000069702

ENSMUSG00000029287

Q03167

O88393

NM_001195683
NM_001195684
NM_003243

NM_011578

NP_001182612
NP_001182613
NP_003234

NP_035708

Betaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight. Betaglycan binds to various members of the TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains. It is not involved directly in TGF-beta signal transduction but by binding to various member of the TGF-beta superfamily at the cell surface it acts as a reservoir of ligand for TGF-beta receptors.

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Wikipedia