Beta-mannosidase
| beta-mannosidase | |||||||
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| Aliases | MANBA, MANB1, mannosidase beta | ||||||
| External IDs | MGI: 88175 HomoloGene: 4317 GeneCards: MANBA | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | Chr 4: 102.63 – 102.76 Mb | Chr 3: 135.49 – 135.57 Mb | |||||
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| Beta-mannosidase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.2.1.25 | ||||||||
| CAS number | 9025-43-8 | ||||||||
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| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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| PMC | articles |
| PubMed | articles |
| NCBI | proteins |
Beta-mannosidase (EC 3.2.1.25, mannanase, mannase, beta-D-mannosidase, beta-mannoside mannohydrolase, exo-beta-D-mannanase, lysosomal beta A mannosidase) is an enzyme with systematic name beta-D-mannoside mannohydrolase, which is in humans encoded by the MANBA gene. This enzyme catalyses the following chemical reaction
This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement.
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