Bcl-2 homologous antagonist killer

BAK1

Protein BAK1 PDB 2ims.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
5AJK, 1BXL, 2IMS, 2IMT, 2JBY, 2JCN, 2LP8, 2M5B, 2XPX, 3I1H, 3QBR, 4D2L, 4U2U, 4U2V, 4UF1, 5FMK, 5FMI

Identifiers

BAK1, BAK, BAK-LIKE, BCL2L7, CDN1, BCL2 antagonist/killer 1

External IDs

MGI: 1097161 HomoloGene: 917 GeneCards: BAK1

Gene location (Human)

Chr.	Chromosome 6 (human)

Band	6p21.31	Start	33,572,547 bp
Band	6p21.31	End	33,580,293 bp

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)

Band	17\|17 A3.3	Start	27,019,810 bp
Band	17\|17 A3.3	End	27,029,009 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• heat shock protein binding • ion channel binding • metal ion binding • protein binding • identical protein binding • protein heterodimerization activity • chaperone binding • BH domain binding • protein homodimerization activity • molecular function
Cellular component	• integral component of membrane • cytosol • membrane • mitochondrial membrane • integral component of mitochondrial outer membrane • intracellular • endoplasmic reticulum • mitochondrion • pore complex • mitochondrial outer membrane • BAK complex
Biological process	• activation of signaling protein activity involved in unfolded protein response • mitochondrial fusion • leukocyte homeostasis • regulation of apoptotic process • positive regulation of endoplasmic reticulum unfolded protein response • establishment or maintenance of transmembrane electrochemical gradient • limb morphogenesis • cytolysis • positive regulation of calcium ion transport into cytosol • response to organic cyclic compound • B cell apoptotic process • regulation of protein heterodimerization activity • positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway • vagina development • homeostasis of number of cells • cellular response to UV • myeloid cell homeostasis • aging • post-embryonic camera-type eye morphogenesis • B cell homeostasis • thymocyte apoptotic process • endoplasmic reticulum calcium ion homeostasis • negative regulation of gene expression • regulation of cell cycle • regulation of mitochondrial membrane potential • positive regulation of IRE1-mediated unfolded protein response • blood vessel remodeling • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • brain development • response to fungus • regulation of mitochondrial membrane permeability • cellular response to mechanical stimulus • fibroblast apoptotic process • activation of cysteine-type endopeptidase activity • apoptotic process involved in blood vessel morphogenesis • activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c • animal organ regeneration • negative regulation of peptidyl-serine phosphorylation • positive regulation of proteolysis • positive regulation of release of cytochrome c from mitochondria • apoptotic signaling pathway • negative regulation of endoplasmic reticulum calcium ion concentration • cell proliferation • response to ethanol • activation of cysteine-type endopeptidase activity involved in apoptotic process • response to gamma radiation • regulation of protein homodimerization activity • response to UV-C • response to hydrogen peroxide • response to drug • endocrine pancreas development • release of cytochrome c from mitochondria • B cell negative selection • negative regulation of cell proliferation • response to mycotoxin • positive regulation of apoptotic process • intrinsic apoptotic signaling pathway in response to DNA damage • extrinsic apoptotic signaling pathway in absence of ligand • apoptotic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


578


12018


ENSG00000030110


ENSMUSG00000057789


Q16611


O08734

RefSeq (mRNA)


NM_001188


NM_007523

RefSeq (protein)


NP_001179


NP_031549

Location (UCSC)

Chr 6: 33.57 – 33.58 Mb

Chr 6: 27.02 – 27.03 Mb

PubMed search

5AJK, 1BXL, 2IMS, 2IMT, 2JBY, 2JCN, 2LP8, 2M5B, 2XPX, 3I1H, 3QBR, 4D2L, 4U2U, 4U2V, 4UF1, 5FMK, 5FMI

ENSG00000030110

ENSMUSG00000057789

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Wikipedia

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