Bcl-2-associated X protein

BAX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BDU, 1F16, 2G5B, 2K7W, 2LR1, 3PK1, 3PL7, 4BD2, 4BD6, 4BD7, 4BD8, 4UF2, 4ZIE, 4ZIF, 4ZIG, 4ZIH, 4ZII, 4S0O
Identifiers
Aliases	BAX, BCL2L4, BCL2 associated X protein, BCL2 associated X, apoptosis regulator
External IDs	OMIM: 600040 MGI: 99702 HomoloGene: 7242 GeneCards: BAX
Gene ontology Molecular function • protein homodimerization activity • channel activity • protein binding • BH3 domain binding • chaperone binding • protein heterodimerization activity • identical protein binding • lipid binding • Hsp70 protein binding Cellular component • cytosol • nuclear envelope • membrane • Bcl-2 family protein complex • mitochondrion • nucleus • mitochondrial permeability transition pore complex • mitochondrial membrane • BAX complex • endoplasmic reticulum • extracellular exosome • pore complex • integral component of membrane • intracellular • endoplasmic reticulum membrane • cytoplasm • mitochondrial outer membrane Biological process • negative regulation of neuron apoptotic process • response to ionizing radiation • germ cell development • positive regulation of calcium ion transport into cytosol • glycosphingolipid metabolic process • B cell apoptotic process • response to salt stress • Sertoli cell proliferation • thymocyte apoptotic process • T cell homeostatic proliferation • post-embryonic development • regulation of mitochondrial membrane permeability involved in apoptotic process • negative regulation of protein binding • cellular response to DNA damage stimulus • regulation of mitochondrial membrane permeability involved in programmed necrotic cell death • odontogenesis of dentin-containing tooth • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of IRE1-mediated unfolded protein response • blood vessel remodeling • positive regulation of neuron apoptotic process • apoptotic process involved in blood vessel morphogenesis • activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c • spermatogenesis • apoptotic signaling pathway • cell proliferation • mitochondrion morphogenesis • activation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of cell proliferation • cellular response to organic substance • activation of signaling protein activity involved in unfolded protein response • B cell homeostatic proliferation • limb morphogenesis • release of matrix enzymes from mitochondria • extrinsic apoptotic signaling pathway • kidney development • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • negative regulation of apoptotic signaling pathway • myeloid cell homeostasis • regulation of neuron apoptotic process • regulation of cysteine-type endopeptidase activity involved in apoptotic process • endoplasmic reticulum calcium ion homeostasis • response to wounding • intrinsic apoptotic signaling pathway by p53 class mediator • hypothalamus development • viral process • protein homooligomerization • response to gamma radiation • negative regulation of fibroblast proliferation • positive regulation of intrinsic apoptotic signaling pathway • response to toxic substance • B cell negative selection • mitochondrial fusion • neuron apoptotic process • male gonad development • positive regulation of B cell apoptotic process • regulation of protein heterodimerization activity • positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway • cellular response to UV • sex differentiation • neuron migration • B cell homeostasis • positive regulation of release of sequestered calcium ion into cytosol • positive regulation of apoptotic process involved in mammary gland involution • nervous system development • spermatid differentiation • development of secondary sexual characteristics • positive regulation of developmental pigmentation • retina development in camera-type eye • response to axon injury • positive regulation of mitochondrial membrane permeability involved in apoptotic process • cerebral cortex development • ovarian follicle development • fertilization • ectopic germ cell programmed cell death • homeostasis of number of cells within a tissue • positive regulation of release of cytochrome c from mitochondria • B cell receptor apoptotic signaling pathway • negative regulation of endoplasmic reticulum calcium ion concentration • regulation of protein homodimerization activity • apoptotic process involved in embryonic digit morphogenesis • leukocyte homeostasis • positive regulation of apoptotic DNA fragmentation • mitochondrial fragmentation involved in apoptotic process • positive regulation of endoplasmic reticulum unfolded protein response • establishment or maintenance of transmembrane electrochemical gradient • homeostasis of number of cells • vagina development • post-embryonic camera-type eye morphogenesis • regulation of mammary gland epithelial cell proliferation • retinal cell programmed cell death • regulation of cell cycle • regulation of mitochondrial membrane potential • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • apoptotic mitochondrial changes • protein oligomerization • regulation of nitrogen utilization • negative regulation of peptidyl-serine phosphorylation • positive regulation of apoptotic process • positive regulation of protein oligomerization • extrinsic apoptotic signaling pathway via death domain receptors • release of cytochrome c from mitochondria • apoptotic process • protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • intrinsic apoptotic signaling pathway • regulation of apoptotic process • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • intrinsic apoptotic signaling pathway in response to DNA damage • extrinsic apoptotic signaling pathway in absence of ligand Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	581	12028
Ensembl	ENSG00000087088	ENSMUSG00000003873
UniProt	Q07812 Q5ZPJ0	Q07813
RefSeq (mRNA)	NM_001291428 NM_001291429 NM_001291430 NM_001291431 NM_004324 NM_138761 NM_138762 NM_138763 NM_138764	NM_007527
RefSeq (protein)	NP_001278357 NP_001278358 NP_001278359 NP_001278360 NP_004315 NP_620116 NP_620118 NP_620119 NP_001278358.1	NP_031553
Location (UCSC)	Chr 19: 48.95 – 48.96 Mb	Chr 7: 45.46 – 45.47 Mb
PubMed search

4BDU, 1F16, 2G5B, 2K7W, 2LR1, 3PK1, 3PL7, 4BD2, 4BD6, 4BD7, 4BD8, 4UF2, 4ZIE, 4ZIF, 4ZIG, 4ZIH, 4ZII, 4S0O

581

12028

ENSG00000087088

ENSMUSG00000003873

Q07812
Q5ZPJ0

...
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