Bcl-2

BCL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN, 5AGW, 5AGX, 5FCG
Identifiers
Aliases	BCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2, apoptosis regulator
External IDs	OMIM: 151430 MGI: 88138 HomoloGene: 527 GeneCards: BCL2
Genetically Related Diseases
chronic lymphocytic leukemia
Targeted by Drug
Gene ontology Molecular function • protein phosphatase binding • transcription factor binding • protein phosphatase 2A binding • channel inhibitor activity • protein homodimerization activity • channel activity • protease binding • protein binding • sequence-specific DNA binding • BH3 domain binding • identical protein binding • protein heterodimerization activity • ubiquitin protein ligase binding Cellular component • cytoplasm • cytosol • nuclear membrane • membrane • mitochondrion • nucleus • mitochondrial membrane • myelin sheath • mitochondrial outer membrane • endoplasmic reticulum • pore complex • integral component of membrane • intracellular • endoplasmic reticulum membrane • nucleoplasm Biological process • negative regulation of neuron apoptotic process • intrinsic apoptotic signaling pathway in response to oxidative stress • ureteric bud development • hemopoiesis • renal system process • organ growth • T cell differentiation in thymus • lymphocyte homeostasis • response to steroid hormone • positive regulation of catalytic activity • ear development • glomerulus development • post-embryonic development • cellular response to DNA damage stimulus • T cell homeostasis • negative regulation of ossification • negative regulation of G1/S transition of mitotic cell cycle • positive regulation of smooth muscle cell migration • regulation of protein localization • cell aging • T cell differentiation • B cell lineage commitment • response to ischemia • regulation of mitochondrial membrane permeability • humoral immune response • defense response to virus • mesenchymal cell development • positive regulation of multicellular organism growth • animal organ morphogenesis • developmental pigmentation • hair follicle morphogenesis • B cell differentiation • cell proliferation • metanephros development • melanocyte differentiation • negative regulation of autophagy • positive regulation of neuron maturation • negative regulation of myeloid cell apoptotic process • cellular response to hypoxia • pigment granule organization • negative regulation of cell proliferation • B cell receptor signaling pathway • cellular response to organic substance • regulation of apoptotic process • response to cytokine • cellular response to glucose starvation • regulation of protein stability • ossification • positive regulation of melanocyte differentiation • axon regeneration • kidney development • actin filament organization • thymus development • negative regulation of intrinsic apoptotic signaling pathway • negative regulation of apoptotic signaling pathway • response to nicotine • spleen development • endoplasmic reticulum calcium ion homeostasis • positive regulation of skeletal muscle fiber development • response to oxidative stress • lymphoid progenitor cell differentiation • positive regulation of peptidyl-serine phosphorylation • CD8-positive, alpha-beta T cell lineage commitment • reactive oxygen species metabolic process • negative regulation of retinal cell programmed cell death • growth • cell growth • branching involved in ureteric bud morphogenesis • gland morphogenesis • positive regulation of cell growth • positive regulation of B cell proliferation • negative regulation of cell growth • response to gamma radiation • positive regulation of intrinsic apoptotic signaling pathway • response to toxic substance • digestive tract morphogenesis • neuron apoptotic process • single organismal cell-cell adhesion • male gonad development • regulation of protein heterodimerization activity • regulation of glycoprotein biosynthetic process • regulation of viral genome replication • female pregnancy • negative regulation of mitochondrial depolarization • protein dephosphorylation • protein polyubiquitination • negative regulation of apoptotic process • cellular calcium ion homeostasis • B cell homeostasis • behavioral fear response • oocyte development • regulation of cell-matrix adhesion • response to iron ion • negative regulation of cell migration • regulation of autophagy • positive regulation of developmental pigmentation • developmental growth • regulation of transmembrane transporter activity • ovarian follicle development • regulation of gene expression • negative regulation of calcium ion transport into cytosol • negative regulation of osteoblast proliferation • homeostasis of number of cells within a tissue • pigmentation • response to radiation • regulation of catalytic activity • peptidyl-threonine phosphorylation • regulation of protein homodimerization activity • negative regulation of anoikis • response to hydrogen peroxide • T cell lineage commitment • cochlear nucleus development • leukocyte homeostasis • regulation of programmed cell death • regulation of calcium ion transport • axonogenesis • negative regulation of cellular pH reduction • response to glucocorticoid • regulation of cell cycle • regulation of mitochondrial membrane potential • melanin metabolic process • focal adhesion assembly • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • B cell proliferation • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • immune system development • apoptotic mitochondrial changes • peptidyl-serine phosphorylation • regulation of nitrogen utilization • cell morphogenesis • positive regulation of cell proliferation • negative regulation of reactive oxygen species metabolic process • response to UV-B • regulation of developmental pigmentation • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • extrinsic apoptotic signaling pathway via death domain receptors • response to drug • release of cytochrome c from mitochondria • negative regulation of mitotic cell cycle • extrinsic apoptotic signaling pathway in absence of ligand • apoptotic process • transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	596	12043
Ensembl	ENSG00000171791	ENSMUSG00000057329
UniProt	P10415	P10417
RefSeq (mRNA)	NM_000633 NM_000657	NM_009741 NM_177410
RefSeq (protein)	NP_000624 NP_000648	NP_033871.2 NP_033871 NP_803129
Location (UCSC)	Chr 18: 63.12 – 63.32 Mb	Chr 1: 106.54 – 106.71 Mb
PubMed search

1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN, 5AGW, 5AGX, 5FCG

596

12043

ENSG00000171791

ENSMUSG00000057329

P10415

P10417

NM_000633
NM_000657

...
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