Basic fibroblast growth factor

FGF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BAS, 1BFB, 1BFC, 1BFF, 1BFG, 1BLA, 1BLD, 1CVS, 1EV2, 1FGA, 1FQ9, 1II4, 1IIL, 2BFH, 2FGF, 2M49, 4FGF, 4OEE, 4OEF, 4OEG
Identifiers
Aliases	FGF2, BFGF, FGF-2, FGFB, HBGF-2, fibroblast growth factor 2
External IDs	MGI: 95516 HomoloGene: 1521 GeneCards: FGF2
Gene ontology Molecular function • cytokine activity • heparin binding • fibroblast growth factor receptor binding • protein binding • ligand-dependent nuclear receptor transcription coactivator activity • chemoattractant activity • growth factor activity • protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity • receptor-receptor interaction Cellular component • extracellular region • nucleus • extracellular space Biological process • release of sequestered calcium ion into cytosol • cell differentiation • negative regulation of fibroblast migration • hyaluronan catabolic process • positive regulation of endothelial cell proliferation • positive regulation of MAP kinase activity • negative regulation of blood vessel endothelial cell migration • positive regulation of endothelial cell chemotaxis to fibroblast growth factor • somatic stem cell population maintenance • positive regulation of phospholipase C activity • extracellular matrix organization • wound healing • negative regulation of cell death • regulation of angiogenesis • nervous system development • cell migration involved in sprouting angiogenesis • MAPK cascade • positive regulation of angiogenesis • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of transcription, DNA-templated • chemotaxis • fibroblast growth factor receptor signaling pathway • chondroblast differentiation • multicellular organism development • growth factor dependent regulation of skeletal muscle satellite cell proliferation • branching involved in ureteric bud morphogenesis • positive regulation of cardiac muscle cell proliferation • activation of MAPK activity • embryonic morphogenesis • angiogenesis • positive regulation of blood vessel endothelial cell migration • positive regulation of cell fate specification • positive regulation of ERK1 and ERK2 cascade • animal organ morphogenesis • regulation of endothelial cell chemotaxis to fibroblast growth factor • phosphatidylinositol biosynthetic process • inositol phosphate biosynthetic process • negative regulation of wound healing • Ras protein signal transduction • positive regulation of cell division • phosphatidylinositol-mediated signaling • signal transduction • positive regulation of transcription from RNA polymerase II promoter • positive regulation of GTPase activity • positive chemotaxis • phosphatidylinositol phosphorylation • peptidyl-tyrosine phosphorylation • positive regulation of sprouting angiogenesis • positive regulation of cell proliferation • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol-3-phosphate biosynthetic process • stem cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2247	14173
Ensembl	ENSG00000138685	ENSMUSG00000037225
UniProt	P09038	P15655
RefSeq (mRNA)	NM_002006	NM_008006
RefSeq (protein)	NP_001997	NP_032032.1 NP_032032
Location (UCSC)	Chr 4: 122.83 – 122.9 Mb	Chr 3: 37.35 – 37.41 Mb
PubMed search

1BAS, 1BFB, 1BFC, 1BFF, 1BFG, 1BLA, 1BLD, 1CVS, 1EV2, 1FGA, 1FQ9, 1II4, 1IIL, 2BFH, 2FGF, 2M49, 4FGF, 4OEE, 4OEF, 4OEG

2247

14173

ENSG00000138685

ENSMUSG00000037225

...
Wikipedia