BW373U86

BW373U86
Identifiers

IUPAC name 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide
Synonyms	(+)-BW373U86
CAS Number	150428-54-9^Y
PubChem (CID)	119029
ChemSpider	106357^N
ChEMBL	CHEMBL25230^Y
Chemical and physical data
Formula	C₂₇H₃₇N₃O₂
Molar mass	435.608 g/mol
3D model (Jmol)	Interactive image
SMILES CCN(CC)C(=O)C1=CC=C(C=C1)C(C2=CC(=CC=C2)O)N3CC(N(CC3C)CC=C)C
InChI InChI=1S/C27H37N3O2/c1-6-16-29-18-21(5)30(19-20(29)4)26(24-10-9-11-25(31)17-24)22-12-14-23(15-13-22)27(32)28(7-2)8-3/h6,9-15,17,20-21,26,31H,1,7-8,16,18-19H2,2-5H3/t20-,21+,26-/m1/s1^N Key:LBLDMHBSVIVJPM-YZIHRLCOSA-N^N
^NY (what is this?)

(+)-BW373U86 is an opioid analgesic drug used in scientific research.

BW373U86 is a selective agonist for the δ-opioid receptor, with approximately 15x stronger affinity for the δ-opioid than the μ-opioid receptor. It has potent analgesic and antidepressant effects in animal studies. In studies on rats, BW373U86 appears to protect heart muscle cells from apoptosis in conditions of ischemia (oxygen deprivation, such as in heart attack). The mechanism for this is complex and may be separate from its delta agonist effects.

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