BTRC (gene)

BTRC

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1P22, 2P64

Identifiers

Aliases

BTRC, BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, bTrCP, bTrCP1, betaTrCP, beta-transducin repeat containing E3 ubiquitin protein ligase

External IDs

MGI: 1338871 HomoloGene: 39330 GeneCards: BTRC

Gene ontology
Molecular function	• protein binding • ligase activity • protein phosphorylated amino acid binding • protein dimerization activity • beta-catenin binding • ubiquitin protein ligase activity • ubiquitin-protein transferase activity
Cellular component	• nucleus • cytoplasm • nucleoplasm • cytosol • SCF ubiquitin ligase complex
Biological process	• cellular response to organic cyclic compound • protein destabilization • regulation of cell cycle • protein catabolic process • G2/M transition of mitotic cell cycle • negative regulation of sequence-specific DNA binding transcription factor activity • regulation of I-kappaB kinase/NF-kappaB signaling • stress-activated MAPK cascade • T cell receptor signaling pathway • negative regulation of transcription, DNA-templated • positive regulation of proteolysis • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • regulation of proteasomal protein catabolic process • regulation of circadian rhythm • mammary gland epithelial cell proliferation • branching involved in mammary gland duct morphogenesis • negative regulation of smoothened signaling pathway • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • rhythmic process • NIK/NF-kappaB signaling • signal transduction • Fc-epsilon receptor signaling pathway • stimulatory C-type lectin receptor signaling pathway • ubiquitin-dependent protein catabolic process • regulation of canonical Wnt signaling pathway • protein dephosphorylation • positive regulation of transcription, DNA-templated • protein ubiquitination • positive regulation of circadian rhythm • Wnt signaling pathway • protein polyubiquitination • viral process • proteasome-mediated ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8945


12234

Ensembl


ENSG00000166167


ENSMUSG00000025217

UniProt


Q9Y297 Q5T1W7


Q3ULA2

RefSeq (mRNA)


NM_001256856 NM_003939 NM_033637


NM_001037758 NM_001286465 NM_001286466 NM_009771

RefSeq (protein)


NP_001243785 NP_003930 NP_378663

NP_001032847.2 NP_001273394.1 NP_001273395.1 NP_033901.1 NP_001032847
NP_001273394 NP_001273395 NP_033901

Location (UCSC)

Chr 10: 101.35 – 101.56 Mb

Chr 19: 45.36 – 45.53 Mb

PubMed search

NM_001256856
NM_003939
NM_033637

NM_001037758
NM_001286465
NM_001286466
NM_009771

NP_001243785
NP_003930
NP_378663

NP_001273394
NP_001273395
NP_033901

...
Wikipedia