BTG2

BTG2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DJU, 3E9V
Identifiers
Aliases	BTG2, PC3, TIS21, BTG family member 2
External IDs	MGI: 108384 HomoloGene: 31406 GeneCards: BTG2
Gene ontology Molecular function • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding Cellular component • extracellular exosome • cytosol Biological process • negative regulation of neuron apoptotic process • negative regulation of translation • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening • associative learning • regulation of transcription, DNA-templated • response to organic cyclic compound • dentate gyrus development • negative regulation of neural precursor cell proliferation • response to mechanical stimulus • response to peptide hormone • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • response to electrical stimulus • response to organic substance • transcription, DNA-templated • cellular response to DNA damage stimulus • central nervous system neuron development • response to organonitrogen compound • neuron differentiation • skeletal muscle cell differentiation • neuron projection development • DNA repair • anterior/posterior pattern specification • protein methylation • negative regulation of cell proliferation • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7832	12227
Ensembl	ENSG00000159388	ENSMUSG00000020423
UniProt	P78543	Q04211
RefSeq (mRNA)	NM_006763	NM_007570
RefSeq (protein)	NP_006754	NP_031596.1 NP_031596
Location (UCSC)	Chr 1: 203.31 – 203.31 Mb	Chr 1: 134.08 – 134.08 Mb
PubMed search

3DJU, 3E9V

7832

12227

ENSG00000159388

ENSMUSG00000020423

P78543

Q04211

NM_006763

NM_007570

NP_006754

NP_031596.1
NP_031596

Protein BTG2 also known as BTG family member 2 or NGF-inducible anti-proliferative protein PC3 or NGF-inducible protein TIS21, is a protein that in humans is encoded by the BTG2 gene (B-cell translocation gene 2) and in other mammals by the homologous Btg2 gene. This protein controls cell cycle progression and proneural genes expression by acting as a transcription coregulator that enhances or inhibits the activity of transcription factors.

The protein BTG2 is the human homolog of the PC3 (pheochromocytoma cell 3) protein in rat and of the Tis21 (tetradecanoyl phorbol acetate-inducible sequence 21) protein in mouse.Tis21 had been originally isolated as a sequence induced by TPA in mouse fibroblasts, whereas PC3 was originally isolated as sequence induced at the beginning of neuron differentiation;BTG2 was then isolated in human cells as sequence induced by p53 and DNA damage.

...
Wikipedia