BRCC3

BRCC3
Identifiers
Aliases	BRCC3, BRCC36, C6.1A, CXorf53, BRCA1/BRCA2-containing complex subunit 3
External IDs	MGI: 2389572 HomoloGene: 11530 GeneCards: BRCC3
Gene ontology Molecular function • enzyme regulator activity • metal ion binding • polyubiquitin binding • peptidase activity • protein binding • hydrolase activity • metallopeptidase activity • thiol-dependent ubiquitin-specific protease activity • Lys63-specific deubiquitinase activity • thiol-dependent ubiquitinyl hydrolase activity Cellular component • cytoplasm • spindle pole • nuclear ubiquitin ligase complex • ubiquitin ligase complex • nucleoplasm • cytoskeleton • nucleus • cytosol • BRCA1-A complex • BRISC complex Biological process • response to ionizing radiation • positive regulation of DNA repair • G2 DNA damage checkpoint • proteolysis • cellular response to DNA damage stimulus • cell division • cell cycle • histone H2A K63-linked deubiquitination • double-strand break repair via nonhomologous end joining • response to X-ray • regulation of catalytic activity • double-strand break repair • DNA repair • covalent chromatin modification • protein deubiquitination • protein K63-linked deubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79184	210766
Ensembl	ENSG00000185515	ENSMUSG00000031201
UniProt	P46736	P46737
RefSeq (mRNA)	NM_001018055 NM_001242640 NM_024332	NM_001166457 NM_001166459 NM_145956
RefSeq (protein)	NP_001018065 NP_001229569 NP_077308	NP_001159929 NP_001159931 NP_666068
Location (UCSC)	Chr X: 155.07 – 155.12 Mb	Chr X: 75.42 – 75.45 Mb
PubMed search

79184

210766

ENSG00000185515

ENSMUSG00000031201

P46736

P46737

NM_001018055
NM_001242640
NM_024332

NM_001166457
NM_001166459
NM_145956

NP_001018065
NP_001229569
NP_077308

NP_001159929
NP_001159931
NP_666068

Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene.

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint. Alternative splicing results in multiple transcript variants.

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