BRCA2

BRCA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N0W, 3EU7
Identifiers
Aliases	BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, breast cancer 2, DNA repair associated
External IDs	MGI: 109337 HomoloGene: 41 GeneCards: BRCA2
Gene ontology Molecular function • DNA binding • H4 histone acetyltransferase activity • H3 histone acetyltransferase activity • protease binding • histone acetyltransferase activity • protein binding • gamma-tubulin binding • single-stranded DNA binding • protein C-terminus binding Cellular component • centrosome • BRCA2-MAGE-D1 complex • secretory granule • nucleoplasm • protein complex • microtubule organizing center • nuclear chromosome, telomeric region • nucleus • cytoskeleton • lateral element • cytoplasm • cytosol Biological process • chordate embryonic development • nucleotide-excision repair • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • hemopoiesis • DNA recombination • regulation of cytokinesis • replication fork protection • centrosome duplication • male meiosis I • negative regulation of mammary gland epithelial cell proliferation • positive regulation of mitotic cell cycle • cytokinesis • chromosome organization • female gonad development • inner cell mass cell proliferation • positive regulation of transcription, DNA-templated • cell aging • telomere maintenance via recombination • brain development • oocyte maturation • histone H3 acetylation • spermatogenesis • intrinsic apoptotic signaling pathway in response to DNA damage • establishment of protein localization to telomere • histone H4 acetylation • cellular response to DNA damage stimulus • cell cycle • cell proliferation • response to gamma radiation • response to UV-C • response to X-ray • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • mitotic recombination-dependent replication fork processing • double-strand break repair via homologous recombination • DNA synthesis involved in DNA repair • DNA repair • strand displacement • double-strand break repair Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	675	12190
Ensembl	ENSG00000139618	ENSMUSG00000041147
UniProt	P51587	P97929
RefSeq (mRNA)	NM_000059	NM_001081001 NM_009765
RefSeq (protein)	NP_000050	NP_001074470.1 NP_033895.2 NP_001074470 NP_033895
Location (UCSC)	Chr 13: 32.32 – 32.4 Mb	Chr 5: 150.52 – 150.57 Mb
PubMed search

BRCA2 repeat
crystal structure of a rad51-brca2 brc repeat complex
Identifiers
Symbol	BRCA2
Pfam	PF00634
InterPro	IPR002093
SCOP	1n0w
SUPERFAMILY	1n0w
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

BRCA-2 helical
structure of a brca2-dss1 complex
Identifiers
Symbol	BRCA-2_helical
Pfam	PF09169
InterPro	IPR015252
SCOP	1iyj
SUPERFAMILY	1iyj
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
structure of a brca2-dss1 complex
Identifiers
Symbol	BRCA-2_OB1
Pfam	PF09103
InterPro	IPR015187
SCOP	1iyj
SUPERFAMILY	1iyj
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
structure of a brca2-dss1 complex
Identifiers
Symbol	BRCA-2_OB3
Pfam	PF09104
InterPro	IPR015188
SCOP	1iyj
SUPERFAMILY	1iyj
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Tower domain
structure of a brca2-dss1 complex
Identifiers
Symbol	Tower
Pfam	PF09121
InterPro	IPR015205
SCOP	1mje
SUPERFAMILY	1mje
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

1N0W, 3EU7

675

12190

ENSG00000139618

ENSMUSG00000041147

P51587

P97929

NM_000059

NM_001081001
NM_009765

NP_000050

NP_001074470.1
NP_033895.2
NP_001074470
NP_033895

BRCA2 and BRCA2 (/ˌbrækəˈtuː/) are a human gene and its protein product, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for the protein) and the official name (breast cancer 2) are maintained by the HGNC. One alternative symbol, FANCD1, recognizes its association with the FANC protein complex. Orthologs, styled Brca2 and Brca2, are common in other mammal species.BRCA2 is a human tumor suppressor gene (specifically, a caretaker gene), found in all humans; its protein, also called by the synonym breast cancer type 2 susceptibility protein, is responsible for repairing DNA.