BRCA1

BRCA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JM7, 1JNX, 1N5O, 1OQA, 1T15, 1T29, 1T2U, 1T2V, 1Y98, 2ING, 3COJ, 3K0H, 3K0K, 3K15, 3PXA, 3PXB, 3PXC, 3PXD, 3PXE, 4IFI, 4IGK, 4JLU, 4OFB, 4U4A, 4Y18, 4Y2G
Identifiers
Aliases	BRCA1, breast cancer 1, early onset, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53, FANCS, breast cancer 1, DNA repair associated
External IDs	OMIM: 113705 MGI: 104537 HomoloGene: 5276 GeneCards: BRCA1
Gene ontology Molecular function • tubulin binding • metal ion binding • enzyme binding • zinc ion binding • damaged DNA binding • protein binding • transcription coactivator activity • androgen receptor binding • RNA binding • ubiquitin protein ligase binding • transcription regulatory region DNA binding • ubiquitin-protein transferase activity • DNA binding • transferase activity Cellular component • BRCA1-BARD1 complex • condensed nuclear chromosome • gamma-tubulin ring complex • BRCA1-A complex • ubiquitin ligase complex • plasma membrane • nucleoplasm • protein complex • intracellular ribonucleoprotein complex • condensed chromosome • cytoplasm • chromosome • nucleus • lateral element Biological process • response to ionizing radiation • centrosome cycle • chromosome segregation • regulation of transcription from RNA polymerase II promoter • protein K6-linked ubiquitination • intrinsic apoptotic signaling pathway in response to DNA damage • cell cycle • double-strand break repair via nonhomologous end joining • apoptotic process • regulation of apoptotic process • regulation of gene expression by genetic imprinting • regulation of transcription, DNA-templated • negative regulation of fatty acid biosynthetic process • G2 DNA damage checkpoint • transcription, DNA-templated • regulation of transcription from RNA polymerase III promoter • fatty acid biosynthetic process • regulation of DNA methylation • negative regulation of intracellular estrogen receptor signaling pathway • protein autoubiquitination • positive regulation of histone H3-K9 methylation • DNA recombination • positive regulation of angiogenesis • response to estrogen • cellular response to indole-3-methanol • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • negative regulation of transcription, DNA-templated • positive regulation of protein ubiquitination • androgen receptor signaling pathway • negative regulation of centriole replication • postreplication repair • lipid metabolic process • cellular response to tumor necrosis factor • positive regulation of DNA repair • fatty acid metabolic process • positive regulation of gene expression • negative regulation of histone H3-K4 methylation • regulation of cell proliferation • negative regulation of reactive oxygen species metabolic process • positive regulation of vascular endothelial growth factor production • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • positive regulation of cell cycle arrest • positive regulation of transcription from RNA polymerase II promoter • positive regulation of histone H4-K20 methylation • DNA double-strand break processing • strand displacement • double-strand break repair via homologous recombination • DNA replication • negative regulation of histone acetylation • regulation of signal transduction by p53 class mediator • protein ubiquitination • positive regulation of histone H3-K4 methylation • DNA repair • DNA synthesis involved in DNA repair • double-strand break repair • positive regulation of histone acetylation • dosage compensation by inactivation of X chromosome • negative regulation of histone H3-K9 methylation • positive regulation of histone H3-K9 acetylation • positive regulation of transcription, DNA-templated • chordate embryonic development • positive regulation of histone H4-K16 acetylation • cellular response to DNA damage stimulus • protein deubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	672	12189
Ensembl	ENSG00000012048	ENSMUSG00000017146
UniProt	P38398	P48754
RefSeq (mRNA)	NM_007294 NM_007295 NM_007296 NM_007297 NM_007298 NM_007299 NM_007300 NM_007301 NM_007302 NM_007303 NM_007305 NM_007306	NM_009764
RefSeq (protein)	NP_009225 NP_009228 NP_009229 NP_009230 NP_009231	NP_033894.3 NP_033894
Location (UCSC)	Chr 17: 43.04 – 43.17 Mb	Chr 11: 101.49 – 101.55 Mb
PubMed search

1JM7, 1JNX, 1N5O, 1OQA, 1T15, 1T29, 1T2U, 1T2V, 1Y98, 2ING, 3COJ, 3K0H, 3K0K, 3K15, 3PXA, 3PXB, 3PXC, 3PXD, 3PXE, 4IFI, 4IGK, 4JLU, 4OFB, 4U4A, 4Y18, 4Y2G

672

...
Wikipedia