BMP4

BMP4
Identifiers
Aliases	BMP4, BMP2B, BMP2B1, MCOPS6, OFC11, ZYME, bone morphogenetic protein 4
External IDs	OMIM: 112262 MGI: 88180 HomoloGene: 7247 GeneCards: BMP4
Gene ontology Molecular function • heparin binding • cytokine activity • co-receptor binding • transforming growth factor beta receptor binding • growth factor activity • BMP receptor binding • protein binding • chemoattractant activity Cellular component • extracellular region • proteinaceous extracellular matrix • extracellular space Biological process • embryonic skeletal system morphogenesis • negative regulation of T cell differentiation in thymus • germ cell development • skeletal system development • mesenchymal cell differentiation involved in renal system development • cardiac septum development • ureteric bud development • positive regulation of protein phosphorylation • renal system process • positive regulation of endothelial cell differentiation • negative regulation of immature T cell proliferation in thymus • bud elongation involved in lung branching • tendon cell differentiation • anatomical structure formation involved in morphogenesis • ureter epithelial cell differentiation • negative regulation of cell cycle • mesenchymal to epithelial transition involved in metanephros morphogenesis • trachea development • post-embryonic development • monocyte differentiation • specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway • blood vessel endothelial cell proliferation involved in sprouting angiogenesis • BMP signaling pathway involved in renal system segmentation • cranial suture morphogenesis • mesonephros development • odontogenesis of dentin-containing tooth • telencephalon regionalization • negative regulation of chondrocyte differentiation • blood vessel development • negative regulation of mitotic nuclear division • angiogenesis • prostate gland morphogenesis • positive regulation of ERK1 and ERK2 cascade • smooth muscle tissue development • BMP signaling pathway involved in heart induction • negative regulation of epithelial cell proliferation • tissue development • metanephric collecting duct development • inner ear receptor cell differentiation • mesodermal cell fate determination • metanephros development • type B pancreatic cell development • regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of cell proliferation • steroid hormone mediated signaling pathway • mammary gland formation • positive regulation of collagen biosynthetic process • renal system development • negative regulation of myoblast differentiation • cell fate commitment • common-partner SMAD protein phosphorylation • glomerular visceral epithelial cell development • SMAD protein signal transduction • ossification • activation of MAPKK activity • kidney development • lung development • ureter smooth muscle cell differentiation • embryonic digit morphogenesis • epithelial-mesenchymal cell signaling • negative regulation of thymocyte apoptotic process • mesenchymal cell differentiation involved in kidney development • negative regulation of cell death • regulation of odontogenesis of dentin-containing tooth • BMP signaling pathway involved in ureter morphogenesis • mesenchymal cell proliferation involved in ureteric bud development • smooth muscle cell differentiation • negative regulation of gene expression • lymphoid progenitor cell differentiation • epithelium development • positive regulation of transcription, DNA-templated • deltoid tuberosity development • negative regulation of prostatic bud formation • growth • heart development • telencephalon development • branching involved in ureteric bud morphogenesis • positive regulation of kidney development • cartilage development • embryonic limb morphogenesis • negative regulation of MAP kinase activity • positive regulation of cartilage development • lens induction in camera-type eye • positive regulation of neuron differentiation • branching involved in prostate gland morphogenesis • regulation of protein import into nucleus • positive regulation of cell differentiation • erythrocyte differentiation • smoothened signaling pathway • camera-type eye development • secondary heart field specification • negative regulation of phosphorylation • regulation of smooth muscle cell differentiation • regulation of cell fate commitment • regulation of branching involved in prostate gland morphogenesis • cell differentiation • positive regulation of branching involved in lung morphogenesis • chondrocyte differentiation • regulation of cartilage development • organ induction • positive regulation of epithelial cell proliferation • epithelial cell proliferation involved in lung morphogenesis • negative regulation of cell proliferation involved in heart morphogenesis • negative regulation of apoptotic process • positive regulation of ossification • endochondral ossification • positive regulation of DNA-dependent DNA replication • regulation of smooth muscle cell proliferation • regulation of morphogenesis of a branching structure • BMP signaling pathway • macrophage differentiation • negative regulation of metanephric comma-shaped body morphogenesis • embryonic skeletal system development • mesenchymal cell proliferation involved in ureter development • osteoblast differentiation • hematopoietic progenitor cell differentiation • positive regulation of BMP signaling pathway • regulation of gene expression • embryonic cranial skeleton morphogenesis • dorsal/ventral neural tube patterning • lung alveolus development • positive regulation of protein binding • anterior/posterior axis specification • negative regulation of transcription, DNA-templated • positive regulation of epidermal cell differentiation • branching morphogenesis of an epithelial tube • trachea formation • specification of animal organ position • negative regulation of glomerular mesangial cell proliferation • positive regulation of smooth muscle cell proliferation • intermediate mesodermal cell differentiation • pulmonary artery endothelial tube morphogenesis • pituitary gland development • positive regulation of cell death • lung morphogenesis • positive regulation of endothelial cell proliferation • bud dilation involved in lung branching • positive regulation of cardiac muscle fiber development • negative regulation of striated muscle tissue development • positive regulation of cell migration • negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway • BMP signaling pathway involved in nephric duct formation • positive regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of mesenchymal cell proliferation involved in ureter development • mesoderm formation • cellular response to growth factor stimulus • glomerular capillary formation • bronchus development • positive regulation of endothelial cell migration • multicellular organism development • negative regulation of metanephric S-shaped body morphogenesis • neural tube closure • vasculature development • positive regulation of gene expression • embryonic morphogenesis • positive regulation of cell proliferation • protein localization to nucleus • positive regulation of apoptotic process • embryonic skeletal joint morphogenesis • regulation of cell differentiation • negative regulation of branching involved in ureteric bud morphogenesis • mesodermal cell differentiation • neuron fate commitment • forebrain development • cloacal septation • bone development • camera-type eye morphogenesis • positive regulation of SMAD protein import into nucleus • negative regulation of glomerulus development • embryonic hindlimb morphogenesis • positive chemotaxis • outflow tract morphogenesis • odontogenesis • negative regulation of transcription from RNA polymerase II promoter • epithelial to mesenchymal transition involved in endocardial cushion formation • cardiac jelly development • cellular response to BMP stimulus • positive regulation of osteoblast differentiation • epithelial tube branching involved in lung morphogenesis • cardiac muscle cell differentiation • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • apoptotic process involved in endocardial cushion morphogenesis • muscular septum morphogenesis • positive regulation of transcription from RNA polymerase II promoter • positive regulation of bone mineralization • cardiac right ventricle morphogenesis • outflow tract septum morphogenesis • membranous septum morphogenesis • aortic valve morphogenesis • pulmonary valve morphogenesis • endocardial cushion development • endoderm development • coronary vasculature development • BMP signaling pathway involved in heart development • pharyngeal arch artery morphogenesis • positive regulation of cell proliferation involved in outflow tract morphogenesis • negative regulation of extrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	652	12159
Ensembl	ENSG00000125378	ENSMUSG00000021835
UniProt	P12644	P21275
RefSeq (mRNA)	NM_001202 NM_130850 NM_130851	NM_007554 NM_001316360
RefSeq (protein)	NP_001193 NP_570911	NP_001303289.1 NP_031580.2
Location (UCSC)	Chr 14: 53.95 – 53.96 Mb	Chr 14: 46.38 – 46.39 Mb
PubMed search

652

12159

ENSG00000125378

ENSMUSG00000021835

P12644

P21275

NM_001202
NM_130850
NM_130851

NM_007554
NM_001316360

NP_001193
NP_570911

NP_001303289.1
NP_031580.2

Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene. BMP4 is found on chromosome 14q22-q23

BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. BMP4 is highly conserved evolutionarily. BMP4 is found in early embryonic development in the ventral marginal zone and in the eye, heart blood and otic vesicle.

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