BMP15

BMP15
Identifiers
Aliases	BMP15, GDF9B, ODG2, POF4, bone morphogenetic protein 15
External IDs	OMIM: 300247 MGI: 1316745 HomoloGene: 3977 GeneCards: BMP15
Gene ontology Molecular function • transforming growth factor beta receptor binding • growth factor activity • cytokine activity Cellular component • cytoplasm • extracellular region • extracellular space Biological process • ovarian follicle development • female gamete generation • positive regulation of pathway-restricted SMAD protein phosphorylation • BMP signaling pathway • regulation of apoptotic process • regulation of MAPK cascade • cell development • granulosa cell development • SMAD protein signal transduction • positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9210	12155
Ensembl	ENSG00000130385	ENSMUSG00000023279
UniProt	O95972	Q9Z0L4
RefSeq (mRNA)	NM_005448	NM_009757
RefSeq (protein)	NP_005439	NP_033887.1 NP_033887
Location (UCSC)	Chr X: 50.91 – 50.92 Mb	Chr X: 6.31 – 6.32 Mb
PubMed search

9210

12155

ENSG00000130385

ENSMUSG00000023279

O95972

Q9Z0L4

NM_005448

NM_009757

NP_005439

NP_033887.1
NP_033887

Bone morphogenetic protein 15 is a protein that in humans is encoded by the BMP15 gene. It's mainly involved in folliculogenesis.

The protein encoded by this gene is a member of the TGF-β superfamily. It is a paracrine signaling molecule involved in oocyte and follicular development. Using Northern blot analysis, BMP15 has been shown to be exclusively expressed in the ovaries. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9.

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