BMP10

BMP10
Identifiers
Aliases	BMP10, entrez:27302
External IDs	OMIM: 608748 MGI: 1338820 HomoloGene: 7644 GeneCards: BMP10
Gene ontology Molecular function • cytokine activity • receptor serine/threonine kinase binding • hormone activity • telethonin binding • protein binding • transforming growth factor beta receptor binding • growth factor activity Cellular component • cytoplasm • extracellular region • cell surface • Z disc • extracellular space Biological process • regulation of apoptotic process • pathway-restricted SMAD protein phosphorylation • regulation of MAPK cascade • heart trabecula formation • SMAD protein signal transduction • negative regulation of cardiac muscle hypertrophy • adult heart development • positive regulation of pathway-restricted SMAD protein phosphorylation • positive regulation of sarcomere organization • positive regulation of cell proliferation involved in heart morphogenesis • cardiac muscle cell proliferation • BMP signaling pathway • positive regulation of cardiac muscle hypertrophy • negative regulation of endothelial cell migration • positive regulation of transcription, DNA-templated • ventricular cardiac muscle tissue morphogenesis • multicellular organism development • heart development • positive regulation of gene expression • cell adhesion • negative regulation of cell migration • positive regulation of cardiac muscle cell proliferation • positive regulation of cartilage development • negative regulation of cell growth • regulation of cardiac muscle hypertrophy in response to stress • atrial cardiac muscle tissue morphogenesis • regulation of cardiac muscle contraction • sarcomere organization • ventricular cardiac muscle cell development • activin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27302	12154
Ensembl	ENSG00000163217	ENSMUSG00000030046
UniProt	O95393	Q9R229
RefSeq (mRNA)	NM_014482	NM_009756
RefSeq (protein)	NP_055297	NP_033886.2 NP_033886
Location (UCSC)	Chr 2: 68.87 – 68.87 Mb	Chr 6: 87.43 – 87.44 Mb
PubMed search

27302

12154

ENSG00000163217

ENSMUSG00000030046

O95393

Q9R229

NM_014482

NM_009756

NP_055297

NP_033886.2
NP_033886

Bone morphogenetic protein 10 (BMP10) is a protein that in humans is encoded by the BMP10 gene.

BMP10 is a polypeptide belonging to the TGF-β superfamily of proteins. It is a novel protein that, unlike most other BMP's, is likely to be involved in the trabeculation of the heart. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP10 is categorized as a BMP since it shares a large sequence homology with other BMP's in the TGF-β superfamily.

...
Wikipedia