BCL9

BCL9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GL7, 2VP7, 2VPB, 2VPD, 2VPE, 2VPG, 3SL9
Identifiers
Aliases	BCL9, LGS, B-cell CLL/lymphoma 9
External IDs	MGI: 1924828 HomoloGene: 3191 GeneCards: BCL9
Gene ontology Molecular function • beta-catenin binding • protein binding • transcription coactivator activity Cellular component • cytoplasm • cis-Golgi network • Golgi apparatus • nucleus • nucleoplasm Biological process • skeletal muscle cell differentiation • canonical Wnt signaling pathway • Wnt signaling pathway • somatic stem cell population maintenance • myotube differentiation involved in skeletal muscle regeneration • positive regulation of transcription from RNA polymerase II promoter • regulation of transforming growth factor beta receptor signaling pathway • beta-catenin-TCF complex assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	607	77578
Ensembl	ENSG00000116128	ENSMUSG00000038256
UniProt	O00512	Q9D219
RefSeq (mRNA)	NM_004326	NM_029933
RefSeq (protein)	NP_004317	NP_084209
Location (UCSC)	Chr 1: 147.54 – 147.63 Mb	Chr 3: 97.2 – 97.3 Mb
PubMed search

2GL7, 2VP7, 2VPB, 2VPD, 2VPE, 2VPG, 3SL9

607

77578

ENSG00000116128

ENSMUSG00000038256

O00512

Q9D219

NM_004326

NM_029933

NP_004317

NP_084209

B-cell CLL/lymphoma 9 protein is a protein that in humans is encoded by the BCL9 gene.

BCL9, together with its paralogue gene BCL9L (BCL9 like or BCL9.2), have been extensively studied for their role as transcriptional beta-catenin cofactors, fundamental for the transcription of Wnt target genes.

BCL9 and BCL9L have been shown to take part in other tissue-specific molecular mechanisms, showing that their role in the Wnt signaling cascade is only one aspect of their mode of action.

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Wikipedia