BCL2-like 1 (gene)

BCL2L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BXL, 1G5J, 1LXL, 1MAZ, 1R2D, 1R2E, 1R2G, 1R2H, 1R2I, 1YSG, 1YSI, 1YSN, 2B48, 2LP8, 2LPC, 2M03, 2M04, 2ME8, 2ME9, 2MEJ, 2O1Y, 2O2M, 2O2N, 2P1L, 2PON, 2YJ1, 2YQ6, 2YQ7, 2YXJ, 3CVA, 3FDL, 3FDM, 3INQ, 3IO8, 3PL7, 3QKD, 3R85, 3SP7, 3SPF, 3WIZ, 3ZK6, 3ZLN, 3ZLO, 3ZLR, 4A1U, 4A1W, 4AQ3, 4BPK, 4C52, 4C5D, 4CIN, 4EHR, 4HNJ, 4IEH, 4PPI, 4QVE, 4QVF, 4QVX, 4TUH, 5AGW, 5AGX, 4Z9V, 5FMK, 5FMJ, 5C3G
Identifiers
Aliases	BCL2L1, Bcl2l1, Bcl(X)L, Bcl-XL, Bcl2l, BclX, bcl-x, bcl2-L-1, BCL-XL/S, BCLXL, BCLXS, PPP1R52, bcl-xS, BCL2L, BCLX, Bcl-X, bcl-xL, BCL2 like 1
External IDs	MGI: 88139 HomoloGene: 7639 GeneCards: BCL2L1
Targeted by Drug
Gene ontology Molecular function • BH3 domain binding • protein binding • identical protein binding • protein kinase binding • protein heterodimerization activity Cellular component • cytoplasm • integral component of membrane • cytosol • centrosome • nuclear membrane • mitochondrial membrane • membrane • Bcl-2 family protein complex • synapse • intracellular • synaptic vesicle membrane • microtubule organizing center • mitochondrial outer membrane • cell junction • mitochondrial matrix • mitochondrion • mitochondrial inner membrane • cytoskeleton • cytoplasmic vesicle • nucleus • endoplasmic reticulum Biological process • negative regulation of neuron apoptotic process • neuron apoptotic process • germ cell development • negative regulation of execution phase of apoptosis • regulation of apoptotic process • response to cytokine • cellular process regulating host cell cycle in response to virus • male gonad development • endocytosis • negative regulation of intrinsic apoptotic signaling pathway • mitotic cell cycle checkpoint • negative regulation of release of cytochrome c from mitochondria • response to virus • negative regulation of apoptotic process • response to cycloheximide • in utero embryonic development • cellular response to alkaloid • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage • cytokinesis • regulation of mitochondrial membrane potential • growth • negative regulation of establishment of protein localization to plasma membrane • regulation of mitochondrial membrane permeability • apoptotic mitochondrial changes • cellular response to gamma radiation • spermatogenesis • positive regulation of cell proliferation • positive regulation of apoptotic process • cellular response to amino acid stimulus • ovarian follicle development • apoptotic process in bone marrow • fertilization • response to radiation • suppression by virus of host apoptotic process • cell proliferation • mitochondrion morphogenesis • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of autophagy • positive regulation of intrinsic apoptotic signaling pathway • negative regulation of anoikis • hepatocyte apoptotic process • release of cytochrome c from mitochondria • intrinsic apoptotic signaling pathway in response to DNA damage • extrinsic apoptotic signaling pathway in absence of ligand • apoptotic process • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	598	12048
Ensembl	ENSG00000171552	ENSMUSG00000007659
UniProt	Q07817 Q5TE64	Q64373
RefSeq (mRNA)	NM_001191 NM_138578 NM_001317919 NM_001317920 NM_001317921 NM_001322239 NM_001322240 NM_001322242	NM_001289716 NM_001289717 NM_001289739 NM_009743
RefSeq (protein)	NP_001182 NP_001304848 NP_001304849 NP_001304850 NP_001309168 NP_001309169 NP_001309171 NP_612815	NP_001276645.1 NP_001276646.1 NP_033873.3 NP_001276645 NP_001276646 NP_001276668 NP_033873
Location (UCSC)	Chr 20: 31.66 – 31.72 Mb	Chr 2: 152.78 – 152.83 Mb
PubMed search

1BXL, 1G5J, 1LXL, 1MAZ, 1R2D, 1R2E, 1R2G, 1R2H, 1R2I, 1YSG, 1YSI, 1YSN, 2B48, 2LP8, 2LPC, 2M03, 2M04, 2ME8, 2ME9, 2MEJ, 2O1Y, 2O2M, 2O2N, 2P1L, 2PON, 2YJ1, 2YQ6, 2YQ7, 2YXJ, 3CVA, 3FDL, 3FDM, 3INQ, 3IO8, 3PL7, 3QKD, 3R85, 3SP7, 3SPF, 3WIZ, 3ZK6, 3ZLN, 3ZLO, 3ZLR, 4A1U, 4A1W, 4AQ3, 4BPK, 4C52, 4C5D, 4CIN, 4EHR, 4HNJ, 4IEH, 4PPI, 4QVE, 4QVF, 4QVX, 4TUH, 5AGW, 5AGX, 4Z9V, 5FMK, 5FMJ, 5C3G

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